Structural relationships and theoretical study of the free energies of electron transfer, electrochemical properties, and electron transfer kinetic of cephalosporin antibiotics derivatives with fullerenes in nanostructure of [R]·C n (R = cefadroxil, cefepime, cephalexin, cefotaxime, cefoperazone and ceftriaxone) supramolecular complexes

Abstract

Structural relationships and theoretical study of the free energies of electron transfer, electrochemical properties, and electron transfer kinetic of cephalosporin antibiotics derivatives with fullerenes in nanostructure of [R]ÁC n (R 5 cefadroxil, cefepime, cephalexin, cefotaxime, cefoperazone and ceftriaxone) supramolecular complexes Avat Arman Taherpour • Doreena Narian • Arezou Taherpour (n = 1-4) were also calculated for these complexes in accordance with the Marcus theory. In this study, was presented the calculated wavelengths (k (n) ; n = 1-4; in nm) of the photoelectron transfer process as well in the nanostructure complexes.

Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

“…The bactericidal action occurs through inhibition of the active site of enzymes called PBPs (penicillin‐binding proteins), which catalyze the synthesis of peptidoglycan, a component that confers rigidity to the cell wall of prokaryotes . The study of this class of compounds is crucial for obtaining their metabolic, pharmacological, toxicological and pharmacokinetic behavior, especially since they are usually prescribed as an alternative to patients who are allergic to penicillin . The electrochemical determination of a number of cephalosporins has been investigated at GCE, boron doped diamond electrodes, dropping mercury electrodes, electrodes modified with CNT or other nanostructured materials, but their redox processes vary depending on the electroactive moieties of each pharmaceutical compound.…”

Синтез и антибактериальная активность гибридных супрамолекулярных комплексов на основе тетрациклина/доксициклина и водорастворимых производных C₆₀-фуллерена

“…Îäíèì èç ïåðñïåêòèâíûõ íàïðàâëåíèé ïðåîäîëåíèÿ ïîäîáíîãî ìåõàíèçìà óñòîé÷èâîñòè ïðåäñòàâëÿåòñÿ ñîçäàíèå ñóïðàìîëåêóëÿðíûõ êîìïëåêñîâ àíòèáèîòèêà ñ Ñ 60 -ôóëëåðåíîì, ñïîñîáíûõ êà÷åñòâåííî èçìåíÿòü åãî áèîäîñòóïíîñòü äëÿ áàêòåðèàëüíûõ êëåòîê-ìèøåíåé [3]. Äîïîëíèòåëüíûìè ïðåäïîñûëêàìè äëÿ ýòîãî ÿâëÿþòñÿ ðàñ÷åòû, ñâèäåòåëüñòâóþùèå î âîçìîaeíîñòè ôîðìèðîâàíèÿ óñòîé÷èâûõ íåêîâàëåíòíûõ êîìïëåêñîâ íåêîòîðûõ âûñøèõ ôóëëåðåíîâ ñ àíòèáèîòèêàìè èç ãðóïïû öåôàëîñïîðèíîâ [4], à òàêaeå îïûò ôèçèêî-õèìè÷åñêîãî àíàëèçà êîìïëåêñîîáðàçîâàíèÿ Ñ 60 -ôóëëåðåíà ñ àíòèáèîòèêîì äîêñîðóáèöèíîì [5].…”

Caracterização voltamétrica e quantificação de compostos de interesse biológico em eletrodos convencionais e modificados com materiais nanoestruturados: antichagásicos e antibióticos

“…e Zn (II), também foi estudada utilizando polarografia [118] e técnicas voltamétricas [119][120][121][122][123][124] e nestes casos, a redução do metal nos complexos geralmente ocorre em potenciais mais negativos do que aqueles observados para o metal na ausência do fármaco.…”