The gas explosion is the most common accident in China's coal mine oil and gas industry, which seriously affects the safety of people's lives and property. Although a lot of energy has been invested, it still cannot completely solve the problem. The fine water mist explosion suppression technology was first applied to the field of fire protection. Due to its many advantages such as environmental protection, cheapness, and high efficiency, it has gradually attracted experts and scholars to study it extensively and achieved many results. But in the field of coal mine disaster prevention and control research and application is relatively few. This paper mainly studies the chemical dynamic characteristics of inert gas to gas explosion in confined space. In this paper, the effect of inert gas on the explosion in confined space is used for experiments. In order to study the effect of inert gas on gas explosion, a medium-sized gas explosion experiment device was used for gas explosion experiments under the conditions of nitrogen volume fractions of 0%, 9%, and 14%. The effects of inert gas nitrogen on the explosion overpressure during gas explosion were compared and analyzed. The results show that nitrogen has good explosion-proof performance, which can significantly reduce gas explosion overpressure, and the maximum reduction can be reduced by more than 90%. When the nitrogen concentration is low, the impact of methane explosion is reduced, but the methane explosion limit range is gradually reduced. At the same time, under the same methane concentration, the effect of adding nitrogen on the methane explosion limit is obvious; filling the gas sample with nitrogen can reducing the concentration of reactants, inhibiting the dissociation of free radicals, reducing the concentration of reaction activation centers, and thereby reducing the intensity of gas explosions. According to the influence rule of inert gas on gas explosion, the influence rule of inert gas on gas explosion is obtained, which provides corresponding reference for improving disaster prevention and reduction capabilities.