Structural studies and biological activity evaluation of Pd(II), Pt(II) and Ru(II) complexes containing N‐phenyl, N`‐(3‐triazolyl)thiourea

Palladium(II) Complexes of 4‐Phenyl‐3‐thiosemicarbazone Ligands: Insights Into Cytotoxic Properties and Mode of Cell Death

“…The absence of the v(NH) and (C=S) modes, as well as the shifting of the stretching mode II to lower wave numbers, may support this. [52] Upon complex formation, the azomethine signal in the 1 H-NMR spectra (Figure S4) was shifted from 8.01-8.55 ppm to 8.35-8.87 ppm. This might be seen as evidence that the azomethine played a role in the development of the complexes.…”

“…The disappearance of the hydrazinic NH signal in the 1 H-NMR spectra of 8-12 (Figure S4) supports enolization of the À NHÀ C=S moiety. [52] The up-field shift of the 1 H-NMR signal of the phenyl-NH may be attributed to the enolization of the À NHÀ C=S group and falling this group in the shielding zone of the thiol group. The 13 C NMR Scheme 1.…”

Design and synthesis of novel thiourea metal complexes with controllable antibacterial properties

“…This again indicates the presence of marked delocalization of electron density in the chelate ring of the complex. [33,34] Unlike the Ni complex, one of the oxazolidine ring moieties is disordered with occupancy of the minor disordered part refined to 0.259 (4). The atom labels of the minor disordered part are indicated by a prime: O2b′, C10b′, C11b′ and corresponding hydrogen atoms.…”

“…The oxygen, nitrogen and sulfur donors of these ligands provide monobasic bidentate (O,S), neutral monodentate (S) and neutral bidentate (O,N) binding modes. [1][2][3][4] Thiourea derivatives and their metal complexes exhibit a vast range of biological activities including antitumour, [5,6] antitubercular, [7,8] insecticidal, antiprotozoal and herbicide activities and they also act as inhibitors for prevention of corrosion of a wide range of metals in various corrosion environments. [9][10][11] Moreover, these compounds have been extensively used as antibacterial agents, which is important in light of a rapid increase of bacterial resistance against known drugs.…”