Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes

Synthesis and Biological Evaluation of Some Polymethoxylated Fused Pyridine Ring Systems as Antitumor Agents

“…Among the derivatives of the first series, the monomethoxylated compounds 7, 9, and 12 exerted better antitumor activity when compared with their corresponding dimethoxylated analogues 10 and 13, besides, the 4-fluorophenyl moiety seemed to be the most favorable substituent. In this view, compound 7 (R = OCH 3 most active member identified in this study with a broad spectrum of activity against about 22 different tumor cell lines belonging to the nine subpanels employed, with particular effectiveness against the breast cancer T-47D cell line (GI 54.7%). Replacement of the fluorine atom with a sulfonamide functional group resulted in two less active compounds 9 and 10, of which the monomethoxylated analog (9, R = OCH 3 ) exhibited a better potential and spectrum of activity especially against the leukemia subpanel tumor cell lines.…”

Synthesis and biological evaluation of some novel tetrahydroquinolines as anticancer and antimicrobial agents

“…Reaction of the 2-aminohydroquinoline derivatives 1-5 with formic acid afforded the targeted 9-methyl-5-substituted-6,7,8,9-tetrahydro-3H-pyrimido [4,5-b]quinolin-4-ones (7)(8)(9)(10)(11). The IR spectra of these compounds were characterized by the absence of the CN group absorption and the presence of new sharp absorption bands at 1695-1715 cm À1 due to the new C¼O groups.…”

“…Twenty-one analogs (1,4,5,7,8,11,12,15,16,24,25,28,30,33,39,40,42,45,46, 48 and 49) were selected to be evaluated for their in vitro cytotoxic effect via the standard MTT method against a panel of three human tumor cell lines: Caucasian breast adenocarcinoma MCF7, hepatocellular carcinoma HepG2 and colon carcinoma HT29. The results of LC 50 (mM), which is the Figure 1.…”

“…A wide range of chemotherapeutic activities have been ascribed to pyridine derivatives including antimicrobial [1][2][3] , antiamoebic 1 , antiparasitic 4 and antiviral 5,6 activities. As far as the antineoplastic potential is concerned, pyridine derivatives were reported to contribute to a variety of anticancer activity including cytotoxic 7,8 , antiproliferative 9 and CDK kinase inhibitory activity 10 . Cyanopyridylureas have been claimed for their properties in treating hyperproliferative and angiogenesis disorders.…”

Organotin(IV) complexes with 2-acetylpyridine benzoyl hydrazones: antimicrobial activity

“…26 The cytotoxic activity of a variety of organotin complexes against tumor cell lines has been demonstrated by some of us. 27,28 In recent works we started an investigation on metal complexes of pyridine-derived hydrazones. [29][30][31] In the present paper organotin(IV) complexes were prepared by reacting [Bu n SnCl 3 ] and [PhSnCl 3 ] with 2-acetylpyridine-benzoyl hydrazone (H2AcPh), 2-acetylpyridine para-chlorobenzoyl hydrazone (H2AcpClPh) and 2-acetylpyridine para-nitro-benzoyl hydrazone (H2AcpNO 2 Ph) (see Figure 1).…”