Structural Studies of N-(2,4,6-trisubstitutedphenyl)-Chloroacetamides, 2,4,6-X₃C₆ H₂ -NHCO-CH_{3_y} Cl_y, (X = CH₃ or Cl and y = 1 -3)

Abstract

The effect of side chain and ring substitutions on the crystal structures of N-(2,4,6-substitutedphenyO-chloroacetamides of the type, 2,4,6-X 3 C 6 H 2 -NHCO-CH 3 _ v Cl y (X = CH 3 or Cl and 1 < y < 3), has been studied by determining the crystal structures of N-(2,4,6-trimethylphenyl)-2-chloroacetamide, 2,4,6-(CH 3 ) 3 C 6 H 2 -NHCO-CH 2 Cl (TMPMCA); N-(2,4,6-trichlorophenyl)-2-chloroacetamide, 2,4,6-Cl 3 C 6 H 2 -NHCO-CH 2 Cl (TCPMCA); N-(2,4,6-trichlorophenyl)-2,2-dichloroacetamide, 2,4,6-Cl 3 C 6 H 2 -NHCO-CHCl 2 (TCPDCA) and N-(2,4,6-trichlorophenyl)-2,2,2-trichloroacetamide, 2,4,6-Cl 3 C 6 H 2 -NHCO-CCl 3 (TCPTCA). The crystal type, space group, formula units and lattice constants in A are: (TMiPMCA); monoclinic, P2,/n, Z = 8, a = 9.029 (5)

N-(3-Methylbenzoyl)benzenesulfonamide

“…Diaryl acylsulfonamides are known as potent antitumor agents against a broad spectrum of human tumor xenografts (colon, lung, breast, ovary and prostate) in nude mice. As part of our studies on the substituent effects on the structures and other aspects of N-(aryl)-amides (Gowda et al, 2000(Gowda et al, , 2007, N-(substitutedbenzoyl)-arylsulfonamides (Gowda et al, 2009), N-chloroarylsulfonamides (Jyothi & Gowda, 2004) and N-bromoarylsulfonamides (Usha & Gowda, 2006), in the present work, the crystal structure of N-(3-methylbenzoyl)benzenesulfonamide has been determined ( Fig.1).…”

Evaluation of N—H...S and N—H...π interactions inO,O′-diethylN-(2,4,6-trimethylphenyl)thiophosphate: a combination of X-ray crystallographic and theoretical studies

“…These electron-poor aromatic groups may be suitable for lpÁ Á Á interaction (lp = lone pair). Typical examples of lpÁ Á Á interactions are the structures with CSD refcodes OBIBIK (Gowda et al, 2000), including the 2,4,6-Cl 3 C 6 H 2 NH group, and JEDSAN (Abad et al, 2006), including the 2,4,6-F 3 C 6 H 2 NH group. In JEDSAN, one other aromatic ring, apart from 2,4,6-F 3 C 6 H 2 , takes part in the lpÁ Á Á interaction.…”

(E)-MethylN′-[(1H-indol-3-yl)methylidene]hydrazinecarboxylate 0.25-hydrate

“…For our studies on the effects of substituents on the structures of N-(aryl)-amides, see: Bhat & Gowda (2000); Gowda et al (2000Gowda et al ( , 2007. For those on N-(arylsulfonyl)-amides, see: Rodrigues et al (2011a,b).…”

“…As part of our studies on the effects of ring and side chain substitutions on the structures of N-(aryl)-amides (Bhat & Gowda, 2000;Gowda et al, 2000Gowda et al, , 2007, N-(arylsulfonyl)-amides (Rodrigues et al, 2011a,b) and N-(aryl)-arylsulfonamides (Gowda et al, 2005), the crystal structure of N,N-bis(4-chlorophenylsulfonyl)-adipamide has been determined (I) (Fig. 1).…”