Structural studies of several solvated potassium salts of tenatoprazole crystallizing as conglomerates

Study of solid-liquid and solid-vapour equilibria in tenatoprazole potassium salt/solvents systems

“…-The kinetic of phase transformations is slow. More particularly, the evolution from the ethanol solvate towards the anhydrous form is consistent with the crucial role of the solvent molecule in the crystal cohesion [4]. …”

“…Nevertheless, the experimental XRPD pattern has great similarities with that of the ethanol solvate 00005-p.2 All these structural data (the superimposition of the calculated and experimental patterns (figure 6), comparison of structures [4], cell parameters and space groups (table 2)) and the stoichiometry of isolated solvates seem to be consistent with the existence of a total solid solution between the methanol and the ethanol solvate.…”

“…Single crystals were coated with glue, and then, stuck on glass fibers and mounted on the full three circles goniometer of a Bruker SMART APEX diffractometer (MoKα, λ = 0.71073 A) with a CCD area detector (see [4] for more details).…”

“…Furthermore, the ethanol molecules play an important role in the crystal cohesion. Indeed, they act as an electrostatic relay between the potassium cation and the tenatoprazole anion [4].…”

“…Moreover, the DITA measurement carried out from the methanol / ethanol mixture 30 / 70 %w/w shows two slope disruptions (figure 11). As the final mixture is an homogeneous liquid, the first disruption corresponds to the limit between a three and a two phase domain and the 00005-p. 4 JEEP 2011 second one to the boundary between a two phase domain and the homogeneous solution. Therefore, owing to the results collected on this system, an experimental isothermal section at 20°C, can be proposed (figure 12).…”