Structural study of a novel acetylide-thiourea derivative and its evaluation as a detector of benzene

Crystal structure of bis(2-((allylcarbamothioyl)imino)-4-methylthiazol-3-ido-κ2 N,S)palladium(II), C16H20N6PdS4

“…Their characteristics as versatile ligands allow them to form stable complexes [3,4]. Many reports have documented the ability of thioureas to coordinate transition metals such as Ni(II), Cu(II), Co(II), Fe(III) [5,6], Zn(II) [7], Pd(II) [8], and Ru(II) [9]. Their diversified use has received attention by various scientific communities including medical [10], analytical chemistry and metallurgy fields [11].…”

Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions

“…Thanks to all research work carried out over the years, a large variety of C-C and C-X bond formations and numerous highly active catalytic combinations are currently available [37][38][39][40][41]. The broad interest of this cross-coupling methodology is thus found in many fields of application [42,43]. Driven by our interest in the preparation of substituted 2-cyanoindoles and in conjunction with our successful previous research on palladium cross-coupling reactions, we explored the reactivity of 3-iodo-indole-2-carbonitrile of the residual iodine.…”

Design, Synthesis, and Docking Study of Acyl Thiourea Derivatives as Possible Histone Deacetylase Inhibitors with a Novel Zinc Binding Group

“…These anilides were prepared as sodium salts in order to keep the amide function stable during the next step which involved the synthesis of the acid chlorides 4e and 5e using thionyl chloride in the presence of 1 equivalent of pyridine [31], thus avoiding the liberation of HCl. Both of the acid chlorides 4e and 5e were used directly in the next step, which involved refluxing them with 1 equivalent of ammonium thoicyanate (relative to 4d and 5d) in acetone [32,33] for 2 h to yield the yellow oily isothiocyanates (4f and 5f). These were used directly in the next step, which involved the reaction with gaseous ammonia.…”