Structural study of a possible neoplasia detected in Mytilus galloprovincialis collected from the Ria of Vigo (NW Spain)

Alonso, Ana Luna; Suárez, Pilar Dies; Alvarez, Cristina Engel de; Juan, F. San; Molíst, Pilar

doi:10.3354/dao047073

Cited by 24 publications

(17 citation statements)

References 14 publications

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“…High loads of some contaminants (as lead, nickel and vanadium) in station 1 (Table 4) may results in the neoplasic disorders observed in X. securis. These tree elements have been reported as citogenics and mutagenics in M. galloprovincialis in the Ria de Vigo (Alonso et al 2001).…”

Section: Pathologymentioning

confidence: 97%

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The mussel Xenostrobus securis: a well-established alien invader in the Ria de Vigo (Spain, NE Atlantic)

et al. 2009

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Biological and habitat characterization of the non-indigenous invasive species Xenostrobus securis was undertaken in the Ria de Vigo. This study included genetic identification of mussel samples collected from introduced and endemic areas, and the assessment of mussel size, population abundance, geographic distribution, pathological condition, and sediment composition of substrata type. The mussel had a marked patchy distribution, being more abundant in brackish sites with fine sediments and high organic matter content. Pathological analysis revealed that X. securis does not play any role as vector for introducing allochthonous pathogens in the Ria de Vigo. Nevertheless, depending on its invasiveness potential, the mussel could be a key host favouring spreading and epizootic outbreaks of marteliosis which is known to be harmful for local bivalve populations. Phylogenetic analyses of the COI gene placed all the resulting sequences in a clade within the genus Xenostrobus and its phylogeny congruent with an Australian/Pacific origin. The COI tree suggests two historical introductions in European waters. One of these invasions seems to have started in Galicia, moving from there towards Italy and France, while the geographical spread of the second invasion cannot be deciphered, although the Australian/Pacific origin of this invasion seems very possible. The 18S network is congruent with one invasion starting in Galicia or in Italy, as the Australian haplotype is closely related to the haplotype found in these areas. Several hypotheses accounting for the colonization history of this species in Galician waters are discussed.

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Section: Pathologymentioning

confidence: 97%

“…Gonadal neoplasia has been also recorded in M. galloprovincialis collected from a raft in the Ría de Vigo, with a mean prevalence of 6% (Alonso et al 2001). The neoplasia detected in X. securis is similar to that observed in a case of germinoma found in a mussel from the Ría do Burgo (Villalba 2006).…”

Section: Pathologymentioning

confidence: 99%

The mussel Xenostrobus securis: a well-established alien invader in the Ria de Vigo (Spain, NE Atlantic)

et al. 2009

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“…In Europe, Alonso et al (2001) reported a possible gonadal neoplasm in Mytillus galloprovincialis from Galicia, Spain. Twomey and Mulcahy (1984) diagnosed hemic neoplasms arising in the gonad of the common cockle Cerastoderma edule and subsequently suggested that this sarcoma may derive from germinal epithelium of the gonad (Twomey and Mulcahy, 1988).…”

mentioning

confidence: 98%

Germinoma in razor clam Ensis arcuatus (Jeffreys, 1865) in Galicia (NW Spain)

Darriba¹,

Iglesias²,

Harshbarger

et al. 2006

Journal of Invertebrate Pathology

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“…Haemocytic leukemia has been reported in Mytilus subspecies along the northwest coast of the United States (Mix 1983;Elston et al 1988;Krishnakumar et al 1999), the United Kingdom (Green and Alderman 1983), Denmark (Rasmussen 1996), Spain (Alonso et al 2001), Chile (Camplans et al 1998), Italy (Zizzo et al 1991), and southern British Columbia (Wong et al 1984;Bower 1989). Haemocytic leukemia outbreaks in Mya have been documented in Chesapeake Bay (Farley et al 1986), New Bedford Harbour (Reinisch et al 1984), Long Island Sound (Brousseau 1987), and Prince Edward Island (McGladdery et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Detecting p53 family proteins in haemocytic leukemia cells ofMytilus edulisfrom Pictou Harbour, Nova Scotia, Canada

St-Jean¹,

Stephens²,

Courtenay³

et al. 2005

Can. J. Fish. Aquat. Sci.

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Evaluating patterns of expression of p53-related proteins in cells is a novel approach in defining environmentally linked diseases. We have examined the induction of haemocytic leukemia in Mytilus edulis by municipal and industrial contaminants in Pictou Harbour, Nova Scotia, Canada. We used a murine monoclonal antibody, 1E10, as a diagnostic reagent to detect leukemic cells. We first characterized the reactivity of 1E10 with both normal and leukemic Mytilus haemocytes by confocal microscopy. We then compared p53 gene family expression (p53, p63-p73, and p97) in normal versus leukemic haemocytes using a panel of monoclonal and polyclonal antibodies to p53 family proteins. The immunochemical data demonstrate that haemocytic leukemia cells of M. edulis differentially express p63-p73 and p97-p120 proteins. We subsequently used 1E10 to diagnose haemocytic leukemia in 500 M. edulis previously deployed 6 months earlier in Pictou Harbour. In the field, Mytilus caged near untreated municipal wastewater and bleached kraft pulpmill effluents have a significantly greater chance of developing haemocytic leukemia than do mussels exposed to reference sites.Résumé : L'évaluation des patterns d'expression des protéines de type p53 dans les cellules est une méthodologie nouvelle pour caractériser les maladies liées à l'environnement. Nous avons suivi l'induction de leucémie hémocytique chez Mytilus edulis par des contaminants municipaux et industriels dans le port de Pictou, Nouvelle-Écosse, Canada. Nous avons utilisé un anticorps monoclonal de souris, 1E10, comme réactif diagnostique pour déceler les cellules leucémiques. Nous avons d'abord caractérisé la réactivité de 1E10 avec des hémocytes normaux et leucémiques de Mytilus par microscopie confocale. Nous avons ensuite comparé l'expression des gènes de la famille p53 (p53, p63-p73 et p97) dans les hémocytes normaux par comparaison aux hémocytes leucémiques au moyen d'une gamme d'anticorps monoclonaux et polyclonaux dirigés contre les protéines de la famille p53. Les données immunochimiques démontrent que les cellules affectées de leucémie hémocytique de M. edulis ont une expression différente des protéines p63-p73 et p97-p120. Nous avons ensuite utilisé 1E10 pour déceler la leucémie hémocytique chez 500 M. edulis placés six mois auparavant dans le port de Pictou, Nouvelle-Écosse. En nature, les Mytilus encagés près des eaux municipales de rejet non traitées et les effluents de papetières à procédé kraft ont une probabilité significativement plus grande de dévelop-per une leucémie hémocytique que les moules exposées à des sites témoins.[Traduit par la Rédaction] St- Jean et al. 2066

show abstract

Structural study of a possible neoplasia detected in Mytilus galloprovincialis collected from the Ria of Vigo (NW Spain)

Cited by 24 publications

References 14 publications

The mussel Xenostrobus securis: a well-established alien invader in the Ria de Vigo (Spain, NE Atlantic)

The mussel Xenostrobus securis: a well-established alien invader in the Ria de Vigo (Spain, NE Atlantic)

Germinoma in razor clam Ensis arcuatus (Jeffreys, 1865) in Galicia (NW Spain)

Detecting p53 family proteins in haemocytic leukemia cells ofMytilus edulisfrom Pictou Harbour, Nova Scotia, Canada

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