Structural, thermal, optical properties and cytotoxicity of PMMA/ZnO fibers and films: Potential application in tissue engineering

Balen, Rodrigo; Costa, Wilian Vidotto da; Andrade, Jéssica de Lara; Piai, Juliana F.; Muniz, Edvani C.; Companhoni, Mychelle Vianna Pereira; Ueda-Nakamura, Tânia; Lima, S.M.; Andrade, Luís Humberto da Cunha; Bittencourt, Paulo Rodrigo Stival; Hechenleitner, Ana Adelina Winkler; Pineda, Edgardo Alfonso Gómez; Fernandes, D.M.

doi:10.1016/j.apsusc.2016.05.122

Cited by 57 publications

(25 citation statements)

References 65 publications

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“…When we started investigating this new material, there were only a few articles, and these only considered applications in engineering and other branches, not dentistry. Last year, expansion was started regarding investigations of PMMA/ZnO NPs composites in the dental fields [21,27,28] because of their good antimicrobial properties. Our research was tasked with showing the fracture resistance of new material on the real tooth PMMA/ZnO NPs denture, while other work was based on testing materials in the form of plates, discs, fibres or films.…”

Section: Synthesis Of Composite Pmma/zno Npsmentioning

confidence: 99%

“…The toxicity depends on many factors, such as the concentration, size and shape of ZnO NPs, their cellular uptake, generation of reactive oxygen species (ROS) and induced inflammatory responses. Recent data showed that the cytotoxicity of PMMA/ZnO NPs composites depends on the concentrations of incorporated ZnO and the degree of its release from the composite [21]. Therefore, each new PMMA/ZnO NPs composite needs to be tested to avoid potentially adverse reactions in recipients during prolonged exposure.…”

Section: Introductionmentioning

confidence: 99%

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Microstructure Characterisation and Identification of the Mechanical and Functional Properties of a New PMMA-ZnO Composite

et al. 2020

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In this research work, we synthesised poly(methyl methacrylate) (PMMA) enriched with 2 wt.% zinc oxide nanoparticles (ZnO) through conventional heat polymerisation and characterised its microstructure. It was found that the distribution of ZnO nanoparticles was homogeneous through the volume of the PMMA. The mechanical testing of the PMMA-ZnO composite primarily included the determination of the compressive properties on real dentures, while density measurements were performed using a pycnometer. The testing of functional properties involved the identification of the colour of the new PMMA-ZnO composite, where pure PMMA acted as a control. In the second step, the PMMA-ZnO cytotoxicity assays were measured in vitro, which were shown to be similar to the control PMMA. Based on this, it could be concluded that the newly formed PMMA-ZnO composite did not induce direct or indirect cytotoxic effects in L929 cell cultures; therefore, according to ISO/DIN 10993-5:2009, this composite was categorised as non-cytotoxic.

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Section: Synthesis Of Composite Pmma/zno Npsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microstructure Characterisation and Identification of the Mechanical and Functional Properties of a New PMMA-ZnO Composite

et al. 2020

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“…Nanofibers/nanowires have superior electrical and physical properties due to their 1-D confined nanostructure, and they have been used in various applications including scaffolds for tissue engineering, optoelectronic devices, chemical transformation, wearable electronics, field-effect transistor, and others [1][2][3][4][5][6][7]. As the most effective technique to produce microfibers and nanofibers by appending a high voltage power to micro-scale flows, the electrospinning (ES) printing has been attracting more and more attention [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Accurate fabrication of aligned nanofibers via a double-nozzle near-field electrospinning

Wang

et al. 2019

THERM SCI

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The near-field electrospinning is considered as one of the most effective techniques to direct-write aligned fibers which can be applied to various high-tech areas, including energy harvester, tissue engineering, and wearable sensors. For large area aligned pattern printing, the multi-nozzle electrohydrodynamic printing is an efficient method to enhance productivity. As a branch of electrohydrodynamic printing technology, the near-field electrospinning is a crucial concern to make an investigation for the formation of aligned nanofibers. Here we fabricated various nanostructures from beaded fibers to aligned fibers and crimped fibers by the double-nozzle near-field electrospinning process. We found three key parameters affecting the process, including the collector speed, the applied voltage, and the electrode-to-collector distance, and the collector speed is the key factor affecting the crimped frequency. This paper provides a reliable experimental basis and theoretical guidance for the multi-nozzle near-field electrospinning to accurately direct-write microfibers and nanofibers.

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“…With the development of micro-and nanoprocess technology, nanofibers have been popular in the research field, such as scaffolds for tissue engineering, flexible display, microfluidic chip, and batteries etc. [1][2][3][4][5][6]. Electrospinning is a simple and economical way to fabricate nanofibers.…”

Section: Introductionmentioning

confidence: 99%

A new circular spinneret system for electrospinning numerical approach and electric field optimization

Zhu

Wang

et al. 2019

THERM SCI

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Electrospinning is believed to be the most effective technique to produce microfibers or nanofibers at large scale, which can be applied in various high-tech areas, including energy harvester, tissue engineering, and wearable sensors. To enhance nanofiber throughput during a multi-needle electrospinning process, it is an effective way to keep the electric field uniform by optimizing electrospinning spinnerets. For this purpose, a novel circular spinneret system is designed and optimized numerically by a 3-D finite element model, the optimal collector shape is also obtained.

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Structural, thermal, optical properties and cytotoxicity of PMMA/ZnO fibers and films: Potential application in tissue engineering

Cited by 57 publications

References 65 publications

Microstructure Characterisation and Identification of the Mechanical and Functional Properties of a New PMMA-ZnO Composite

Microstructure Characterisation and Identification of the Mechanical and Functional Properties of a New PMMA-ZnO Composite

Accurate fabrication of aligned nanofibers via a double-nozzle near-field electrospinning

A new circular spinneret system for electrospinning numerical approach and electric field optimization

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