Structural Transformations of Myocytes during Gestation and Early Postpartum Involution of the Uterus

Shkurupiy, V. A.; Dubinin, E. V.; Dubinina, N. N.

doi:10.1007/s10517-009-0403-8

Cited by 3 publications

(7 citation statements)

References 9 publications

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“…The size of both myocytes and their nuclei decreased compared to the corresponding values in intact mice ( Table 2). At the same time, myocytes referred by us to types 3 and 4 [4] (in the state of vacuolar and balloon degeneration) and sometimes necrotic myocytes were found during the involution period in multigravida mice. The relative counts of type 3 and 4 myocytes in the myometrium were maximum before delivery and were similar in primigravida and multigravida mice.…”

Section: Notementioning

confidence: 84%

“…The preparations were morphometried at ×400 using a closed test system consisting of 25 squares with an area of 1600 μ 2 . We measured volume densities (Vv) of myocyte nuclei and cytoplasm, myometrium and its vessels, collagen fi bers in the myometrium stroma, and myocytes in the state of vacuolar (type 3) and balloon (type 4) degeneration [4]. Moreover, numerical densities (Nai) of myocytes, their nuclei, and perpendicular and tangential profi les of blood vessels were evaluated.…”

Section: Methodsmentioning

confidence: 99%

“…increases with increasing the number of pregnancies. The muscular layer of the uterus undergoes considerable changes during pregnancy and after delivery [3,4]. The most important events are the increase in myometrium weight during pregnancy and its involution in the postpartum period, when its weight returns to the initial value; the latter process is considerably less studied.…”

mentioning

confidence: 99%

“…The most important events are the increase in myometrium weight during pregnancy and its involution in the postpartum period, when its weight returns to the initial value; the latter process is considerably less studied. It was shown that myometrium growth during the fi rst pregnancy is determined by its hypertrophy, while postpartum involution is realized via autophagocytosis, apoptosis, clasmocytosis, and necrosis [3,4]. However, the peculiarities of myometrium hypertrophy in repeated pregnancies and its postpartum involution as well as possible mechanisms of reparation of lost structures are poorly studied.…”

mentioning

confidence: 99%

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Structural Manifestations of Mechanisms of Myometrium Involution after Repeated Pregnancies in Mice

2010

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Myocyte hypertrophy and proliferation in the myometrium were observed in mice during the first pregnancy and involution of the myometrium was completed by day 10 postpartum. Parameters of all structures returned to values observed in intact uterus. During the third pregnancy, the processes of myometrium hypertrophy were similar to those during the first pregnancy, but the intensity of proliferation was higher against the background of poorer vascularization, which led to destruction of some myocytes. Postpartum involution of the myometrium in these mice was not completed by day 10 after delivery. We observed hypertrophy and proliferation of some myocytes followed by their destruction, decrease in vessel number, and many-fold decrease in collagen content in the myometrial interstitium. The number of fetuses in the litter decreased after multiple pregnancies.

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Section: Notementioning

confidence: 84%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Structural Manifestations of Mechanisms of Myometrium Involution after Repeated Pregnancies in Mice

2010

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“…Postpartum involution of the uterus involves all its structures: the endometrium [4] and myometrium [5,6] with involvement of the myometrial interstitium components: collagen and vessels [3]. It was shown that during 5 days of the involution period after the fi rst pregnancy rats develop myocyte necrosis and apoptosis, autophagocytosis and clasmocytosis of their cytoplasm; each of these processes can be regarded as a mechanism of physical and functional elimination of myometrial structures "excessive" for that period [5,6].…”

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confidence: 99%

Morphological Study of the Main Mechanisms of Myometrium Involution after Repeated Pregnancies in Mice

2011

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Elimination of "excessive" myocytes and their structures during involution of the myometrium after the first and third pregnancies was realized by clasmocytosis (eliminating the greatest volume of myocyte cytoplasm fragments), apoptosis, and necrosis (equal percentage by volume). In contrast to the first pregnancy, involution after the third one was not over by day 10 because of inhibited elimination of functionally lost myocytes by necrosis and apoptosis mechanisms. Presumably, this was caused by slower hydrolysis of apoptotic bodies by macrophages. The concentration of macrophages in the myometrium on day 10 of the involution period in females after the third delivery was 4-fold higher than in intact mice and in females after the first delivery during the same period.

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Apoptosis in Living Animals Is Assisted by Scavenger Cells and Thus May Not Mainly Go through the Cytochrome C-Caspase Pathway

Liu¹,

Xu²,

Man³

et al. 2013

J. Cancer

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Because billions of cells die every day in their bodies, animals have evolutionarily developed apoptosis to preserve the tissue environment from adverse effects of dead cells, a process achieved via phagocytosis of the cell corpses by professional or amateur phagocytes that are collectively referred to as scavengers. Hence, apoptosis is a merger of two procedures separately occurring inside the dying and the scavenger cells, respectively. The task of apoptosis research is to study how these death procedures occur without hurting the host tissues, and recruitment of in vitro system into the study must be justified for this purpose. Cells in culture have no motivation to preserve the environment, and their death does not involve corpse clearance by scavengers. Therefore, programmed cell death in culture should be redefined, for example as stress-induced cell death, to avoid many sources of confusions, since the word “apoptosis” had already been defined, prior to the era of cell culture, as a silent and beneficial cell suicide with corpse clearance as a distinctive hallmark. We should start over again on apoptosis research by determining whether different physiological apoptotic procedures in animals involve the cytochrome c-caspase pathway, since it has been established from cultured cells as a central mechanism of “apoptosis” but whether it overarches any physiological apoptotic procedure in animals is still unclear. Probably, cells in living animals are programmed to use scavengers to assist their apoptosis but cells in culture have no scavengers to help and thus need to go mainly through the cytochrome c-caspase pathway.

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Structural Transformations of Myocytes during Gestation and Early Postpartum Involution of the Uterus

Cited by 3 publications

References 9 publications

Structural Manifestations of Mechanisms of Myometrium Involution after Repeated Pregnancies in Mice

Structural Manifestations of Mechanisms of Myometrium Involution after Repeated Pregnancies in Mice

Morphological Study of the Main Mechanisms of Myometrium Involution after Repeated Pregnancies in Mice

Apoptosis in Living Animals Is Assisted by Scavenger Cells and Thus May Not Mainly Go through the Cytochrome C-Caspase Pathway

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