Structural white matter alterations in male adults with high functioning autism spectrum disorder and concurrent depressive symptoms; a diffusion tensor imaging study

Mohajer, Bahram; Masoudi, Maryam; Ashrafi, Agaah; Mohammadi, Esmaeil; Ershadi, Amir Sasan Bayani; Aarabi, Mohammad Hadi; Uban, Kristina A.

doi:10.1016/j.jad.2019.08.010

Cited by 9 publications

(5 citation statements)

References 46 publications

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“…Previous studies that used varied approaches to diffusion-weighted imaging data have found evidence for WM microstructural abnormalities in adults with autism in the ATR [ 3 , 4 ], ALIC [ 23 ], CC [ 2 , 4 – 6 , 21 , 22 , 24 , 49 ], cingulum [ 2 , 3 , 21 , 24 ], forceps minor and major [ 21 ], IFOF [ 4 , 21 , 22 , 49 ], ILF [ 3 , 4 , 21 , 22 , 49 ], SLF [ 3 , 4 , 21 – 23 , 49 ], and UF [ 2 – 4 , 21 , 49 ], which is broadly neuroanatomically consistent with our findings. This shows the robustness of the diffusion MRI data analysis pipeline used in the current study.…”

Section: Discussionmentioning

confidence: 99%

Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism

et al. 2021

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Background Evidences suggesting the association between behavioral anomalies in autism and white matter (WM) microstructural alterations are increasing. Diffusion tensor imaging (DTI) is widely used to infer tissue microstructure. However, due to its lack of specificity, the underlying pathology of reported differences in DTI measures in autism remains poorly understood. Herein, we applied neurite orientation dispersion and density imaging (NODDI) to quantify and define more specific causes of WM microstructural changes associated with autism in adults. Methods NODDI (neurite density index [NDI], orientation dispersion index, and isotropic volume fraction [ISOVF]) and DTI (fractional anisotropy [FA], mean diffusivity [MD], axial diffusivity, and radial diffusivity [RD]) measures were compared between autism (N = 26; 19 males and 7 females; 32.93 ± 9.24 years old) and age- and sex-matched typically developing (TD; N = 25; 17 males and 8 females; 34.43 ± 9.02 years old) groups using tract-based spatial statistics and region-of-interest analyses. Linear discriminant analysis using leave-one-out cross-validation (LDA-LOOCV) was also performed to assess the discriminative power of diffusion measures in autism and TD. Results Significantly lower NDI and higher ISOVF, suggestive of decreased neurite density and increased extracellular free-water, respectively, were demonstrated in the autism group compared with the TD group, mainly in commissural and long-range association tracts, but with distinct predominant sides. Consistent with previous reports, the autism group showed lower FA and higher MD and RD when compared with TD group. Notably, LDA-LOOCV suggests that NDI and ISOVF have relatively higher accuracy (82%) and specificity (NDI, 84%; ISOVF, 88%) compared with that of FA, MD, and RD (accuracy, 67–73%; specificity, 68–80%). Limitations The absence of histopathological confirmation limit the interpretation of our findings. Conclusions Our results suggest that NODDI measures might be useful as imaging biomarkers to diagnose autism in adults and assess its behavioral characteristics. Furthermore, NODDI allows interpretation of previous findings on changes in WM diffusion tensor metrics in individuals with autism.

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Section: Discussionmentioning

confidence: 99%

Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism

et al. 2021

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“…Impaired WM integrity is more often seen in association with depressive symptoms in other neurological and psychiatric disorders, including cerebral small vessel disease (SVD) [73,74], multiple sclerosis [75,76], Parkinson's disease [77,78], schizophrenia [79,80], bipolar disorder [81,82], and autism spectrum disorder [83,84]. For instance, Brooker et al used path analyses in cross-sectional data to model the relationships among depression, disability, and disability on quality of life (QoL) in SVD stroke and non-SVD stroke patients.…”

Section: White Matter Integrity In Depressionmentioning

confidence: 99%

Oligodendrocyte lineage cells and depression

et al. 2020

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Depression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There are data to support several different theories of causation, including the monoamine hypothesis, hypothalamic–pituitary–adrenal axis changes, inflammation and immune system alterations, abnormalities of neurogenesis and a conducive environmental milieu. Research in these areas and others has greatly advanced the current understanding of depression; however, there are other, less widely known theories of pathogenesis. Oligodendrocyte lineage cells, including oligodendrocyte progenitor cells and mature oligodendrocytes, have numerous important functions, which include forming myelin sheaths that enwrap central nervous system axons, supporting axons metabolically, and mediating certain forms of neuroplasticity. These specialized glial cells have been implicated in psychiatric disorders such as depression. In this review, we summarize recent findings that shed light on how oligodendrocyte lineage cells might participate in the pathogenesis of depression, and we discuss new approaches for targeting these cells as a novel strategy to treat depression.

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“…ASD is defined as a neuro-developmental disorder in which brain function is affected. It is a widespectrum disorder affecting social communication, characterized by limited attention, repetitive involuntary movements, obsessive behaviors, learning difficulties (Giannopulu and Pradel, 2010;Lim et al, 2019;Masi et al, 2017;Mohajer et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Does Function Level of Individuals With Autism Spectrum Disorder Affect The Family Impact?

Öztürk

Karabıçak

Cavlak

2023

International Journal of Disabilities Sports and Health Sciences

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Objective: The aim of our study is to examine the effect of differences in the levels of functionality of individuals with autism spectrum disorder (ASD) on level of family involvement. Methods: Our study has been carried out with the relatives of ASD individuals attending Aydın Efeler Municipality Autism Sports and Life Center. The functional independence levels of children was assesed by using The Pediatric Functional Independence Criterion (WeeFIM), and The Family Impact Scale (FIS) was used to measure the impact on the families of children with chronic disabilities. Results: Our study was completed with the assessment of 98 individuals diagnosed with ASD (age=10.17±5.11, gender=15 female/83 male) and 98 pairs of their parents. As a result of the study, the total WeeFim score was determined as 94.73 ±20.26 (independent) and the family impact scale scores were determined as 63.03 ± 12. The correlation analysis showed the sub WeeFIM impact the financial burden my family, self-care, communication, social status were statistically significant and weak correlation score between the total score (p

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Structural white matter alterations in male adults with high functioning autism spectrum disorder and concurrent depressive symptoms; a diffusion tensor imaging study

Cited by 9 publications

References 46 publications

Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism

Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism

Oligodendrocyte lineage cells and depression

Does Function Level of Individuals With Autism Spectrum Disorder Affect The Family Impact?

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