Structurall features of the pancreas in patients with type 1 diabetes mellitus

Ragimov, M. R.; Nikonova, Tatiana Vasil'evna; Babaeva, Diana; Vladimirova, V P; Shestakova, Marina Vladimirovna

doi:10.14341/dm12892

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Pancreatic islets vary considerably in size up to 500 μm, but a typical islet is about 50–200 μm in diameter ( Dolenšek et al, 2015 ; Ionescu-Tirgoviste et al, 2015 ). It should be noted that pancreatic volume and size are reduced in T1DM patients, and this is affected by the duration and age of disease onset ( Ragimov et al, 2022 ).…”

Section: The Pancreas and The Main Stages Of Its Developmentmentioning

confidence: 99%

Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators

Chernysheva,

Ruchko,

Karimova

et al. 2024

Front. Cell Dev. Biol.

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Pancreatic regeneration is a complex process observed in both normal and pathological conditions. The aim of this review is to provide a comprehensive understanding of the emergence of a functionally active population of insulin-secreting β-cells in the adult pancreas. The renewal of β-cells is governed by a multifaceted interaction between cellular sources of genetic and epigenetic factors. Understanding the development and heterogeneity of β-cell populations is crucial for functional β-cell regeneration. The functional mass of pancreatic β-cells increases in situations such as pregnancy and obesity. However, the specific markers of mature β-cell populations and postnatal pancreatic progenitors capable of increasing self-reproduction in these conditions remain to be elucidated. The capacity to regenerate the β-cell population through various pathways, including the proliferation of pre-existing β-cells, β-cell neogenesis, differentiation of β-cells from a population of progenitor cells, and transdifferentiation of non-β-cells into β-cells, reveals crucial molecular mechanisms for identifying cellular sources and inducers of functional cell renewal. This provides an opportunity to identify specific cellular sources and mechanisms of regeneration, which could have clinical applications in treating various pathologies, including in vitro cell-based technologies, and deepen our understanding of regeneration in different physiological conditions.

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Section: The Pancreas and The Main Stages Of Its Developmentmentioning

confidence: 99%

Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators

Chernysheva,

Ruchko,

Karimova

et al. 2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

A clinical case of exocrine pancreatic insufficiency in a patient with type 1 diabetes mellitus

et al. 2023

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The pancreas belongs to the glands of mixed secretion and simultaneously performs both endo- and exocrine functions. Exocrine pancreatic insufficiency (EPI) is the general name for the malabsorption process caused by inadequate production and decreased activation of the enzymes of the pancreas acinar cells, such as amylase, lipase and protease, which are necessary for digestion. The prevalence of EPI in patients with type 1 diabetes, according to many authors, varies from 25 to 59%, which is determine by the data of pancreatic elastase-1. In this work, we present a clinical case of confirmed exocrine pancreatic insufficiency in a patient with a 6-year history of type 1 diabetes, which became the main cause of the development of episodes of hypoglycemia after meals. In the course of further studies, antibodies to lactoferrin and a reduced prostate volume, determined by MRI data, high levels of antibodies to glutamate decarboxylase and zinc co-transporter 8, as well as residual insulin secretion based on the level of C-peptide on an empty stomach detected.

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Structurall features of the pancreas in patients with type 1 diabetes mellitus

Cited by 2 publications

References 20 publications

Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators

Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators

A clinical case of exocrine pancreatic insufficiency in a patient with type 1 diabetes mellitus

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