Structurally analogous trehalose and sucrose glycopolymers – comparative characterization and evaluation of their effects on insulin fibrillation

Abstract

Comprehensive comparative characterization of highly structurally similar, RAFT-prepared trehalose and sucrose glycopolymers.

Peptide Inhibitors of Insulin Fibrillation: Current and Future Challenges

“…Among nanoparticles (NPs), those studied against insulin fibrillation include silicon NPs [ 62 ], ceria NPs [ 63 ], magnetite NPs [ 64 ], gold NPs [ 65 ], silver NPs [ 66 ], graphene oxide [ 67 ], organic NPs [ 68 ], carbon dots [ 69 , 70 , 71 ], and quantum dots [ 72 ]. Among molecules, there are glycopolymers [ 73 , 74 ], amphiphiles [ 75 ], aromatic molecules [ 76 ], polyphenols [ 6 , 77 , 78 ], vitamins [ 79 ], dyes [ 80 ], and various drugs [ 81 ]. The idea of the inhibition of amyloid aggregation, especially for insulin, is that molecules with hydrophobic functionalities can sequester the aggregation-prone regions of the target protein and inhibit its aggregation, while exposing more hydrophilic groups to assist with solubility.…”

The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes

“…Second, trehalase-resistant trehalose analogs augment bioavailability and potency over trehalase-labile trehaloses ( 40 , 52 ). Third, trehalose polymers, pTreA20 and pTreA40, resist degradation by trehalases ( 66 ). On these bases, we tested the hypothesis that trehalase-resistant polymers induce fasting-like hepatocellular signals.…”

Polyisobutylene-based glycopolymers as potent inhibitors for in vitro insulin aggregation

“…35,36 In view of this, numerous research studies have been attempted to enhance the effectivity of sugar-based osmolytes as molecular chaperones, amongst which polymeric sugar-based chaperones have shown effectively enhanced protein stabilizing properties using heat as the external stimulus. 37,38 It was observed that sugar clusters can enhance the rate of inhibition of insulin fibril formation compared to molecular sugar, establishing the multivalent binding effect of polymeric sugar with insulin proteins for inhibiting aggregation. 39 The ability of a trehalose glycopolymer to prevent the production of amyloid fibrils was found to be superior to monomeric trehalose.…”