2009
DOI: 10.1002/adma.200901971
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Structurally Controlled Bio‐hybrid Materials Based on Unidirectional Association of Anisotropic Microparticles with Human Endothelial Cells

Abstract: Biocompatible anisotropic polymer particles with bipolar affinity towards human endothelial cells are a novel type of building blocks for microstructured bio-hybrid materials. Functional polarity due to two biologically distinct hemispheres has been achieved by synthesis of anisotropic particles via electro-hydrodynamic co-jetting of two different polymer solutions and subsequent selective surface modification.

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Cited by 109 publications
(98 citation statements)
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“…[12] Methods for preparing Janus particles can be divided into direct chemical synthesis, chemical modification of particles at biphasic interfaces and topographically selective modification of particles. [13][14][15] Janus particles were prepared by microfluidics, [16] wet-chemical synthesis, [16,17] plasma polymerization [18] or electrohydrodynamic co-jetting, [11,15] and are limited by the choice of materials suitable for these techniques. Such a limitation can be overcome by topographically selective modification, allowing for versatile surface composition.…”
Section: Doi: 101002/adma201103958mentioning
confidence: 99%
“…[12] Methods for preparing Janus particles can be divided into direct chemical synthesis, chemical modification of particles at biphasic interfaces and topographically selective modification of particles. [13][14][15] Janus particles were prepared by microfluidics, [16] wet-chemical synthesis, [16,17] plasma polymerization [18] or electrohydrodynamic co-jetting, [11,15] and are limited by the choice of materials suitable for these techniques. Such a limitation can be overcome by topographically selective modification, allowing for versatile surface composition.…”
Section: Doi: 101002/adma201103958mentioning
confidence: 99%
“…Although there are numerous studies on CuAAC functionalization of nonporous polymers [280,298,328,[336][337][338][339][340][341][342][343][344][345][346][347][348][349][350][351], silica [352][353][354] and metal particles [355], the amount of publications on porous polymer particles is limited. Finn et al [356] described the click functionalization of a commercial porous agarose resin for affinity chromatography.…”
Section: Cu(i) Catalyzed Azide-alkyne Cycloaddition (Cuaac)mentioning
confidence: 99%
“…One way is analyzing microscopy images via various available software [218,241], which will also calculate the average size. Light scattering [278][279][280] and electrical sensing zone (also called Coulter counter) [45,[281][282] are rather sensitive instrument-based methods to determine size and size distribution. Microscopy and image analysis combination can be considered as the easiest method.…”
Section: Size and Size Dispersitymentioning
confidence: 99%
“…Compared to spherical symmetric particles, anisotropic particles have distinct physical and/or chemical properties because of their broken symmetry, which are also widely observed in organisms (e.g., proteins, lipids, and self-organized superstructures) [4]. As one important class of anisotropic particles, Janus particles, which were named after the ancient Roman god Janus [5], have distinct properties on opposing sides, endowing themselves with amphiphilic behavior [6], catalytic activity [7], magnetic response [8,9], localization and rotation in electric fields [10], cell targeting [11], etc.…”
Section: Introductionmentioning
confidence: 99%