Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades

Hisano, Kazutoshi; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori; Yamada, Hiroki; Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi

doi:10.1016/j.bbrc.2020.11.119

Cited by 21 publications

(13 citation statements)

References 27 publications

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“…Various lipid classes and individual lipid metabolites are not only important for cellular metabolism, they are also important regulators of cellular proliferation and survival through their function as extracellular signaling molecules that bind to specific cellular receptors or modulate intracellular signaling through their molecular interactions in cellular membranes (e.g., anchoring of cell surface membrane molecules) [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. Furthermore, pretransplant biological characteristics have an impact on prognosis/survival after allogeneic stem cell transplantation [ 13 ], and lipid metabolites also seem to be involved in the regulation of proliferation and survival of myeloid malignant cells [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients

Hatfield

Bruserud

Reikvam

2022

Cancers

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Allogeneic stem cell transplantation is used in the treatment of high-risk hematological malignancies. However, this treatment is associated with severe treatment-related morbidity and mortality. The metabolic status of the recipient may be associated with the risk of development of transplant-associated complications such as graft-versus-host disease (GVHD). To better understand the impact of the lipidomic profile of transplant recipients on posttransplant complications, we evaluated the lipid signatures of patients with hematological disease using non-targeted lipidomics. In the present study, we studied pretransplant serum samples derived from 92 consecutive patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). A total of 960 lipid biochemicals were identified, and the pretransplant lipidomic profiles differed significantly when comparing patients with and without the risk factors: (i) pretransplant inflammation, (ii) early fluid overload, and (iii) patients with and without later steroid-requiring acute GVHD. All three factors, but especially patients with pretransplant inflammation, were associated with decreased levels of several lipid metabolites. Based on the overall concentrations of various lipid subclasses, we identified a patient subset characterized by low lipid levels, increased frequency of MDS patients, signs of inflammation, decreased body mass index, and an increased risk of early non-relapse mortality. Metabolic targeting has been proposed as a possible therapeutic strategy in allotransplant recipients, and our present results suggest that the clinical consequences of therapeutic intervention (e.g., nutritional support) will also differ between patients and depend on the metabolic context.

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Section: Discussionmentioning

confidence: 99%

Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients

Hatfield

Bruserud

Reikvam

2022

Cancers

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“…Two mechanisms potentially explain the impact of LPEs on BMI. First, LPEs could stimulate calcium ion (Ca 2+ ) signaling and elevate intracellular Ca 2+ level (31,32), which can inhibit the differentiation of preadipocytes into mature adipocytes in both cell lines (33,34) and animal models (35). Second, obesity is characterized by chronic inflammation (36), and LPEs could regulate body weight through inhibiting the production of proinflammatory cytokines and promoting the secretion of anti‐inflammation cytokine interleukin (IL)‐10 (37,38).…”

Section: Discussionmentioning

confidence: 99%

“…These findings provided mechanistic insight into the smoking-BMI association. level (31,32), which can inhibit the differentiation of preadipocytes into mature adipocytes in both cell lines (33,34) and animal models (35). Second, obesity is characterized by chronic inflammation (36),…”

Section: Discussionmentioning

confidence: 99%

Examination of serum metabolome altered by cigarette smoking identifies novel metabolites mediating smoking‐BMI association

Zhang

Sun

Huang

et al. 2022

Obesity

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Objective The authors hypothesize that an untargeted metabolomics study will identify novel mechanisms underlying smoking‐associated weight loss. Methods This study performed cross‐sectional analyses among 1,252 participants in the Bogalusa Heart Study and assessed 1,202 plasma metabolites for mediation effects on smoking‐BMI associations. Significant metabolites were tested for associations with smoking genetic risk scores among a subset of participants (n = 654) with available genomic data, followed by direction dependence analysis to investigate causal relationships between the metabolites and smoking and BMI. All analyses controlled for age, sex, race, education, alcohol drinking, and physical activity. Results Compared with never smokers, current and former smokers had a 3.31‐kg/m2 and 1.77‐kg/m2 lower BMI after adjusting for all covariables, respectively. A total of 22 xenobiotics and 94 endogenous metabolites were significantly associated with current smoking. Eight xenobiotics were also associated with former smoking. Forty metabolites mediated the smoking‐BMI associations, and five showed causal relationships with both smoking and BMI. These metabolites, including 1‐oleoyl‐GPE (18:1), 1‐linoleoyl‐GPE (18:2), 1‐stearoyl‐2‐arachidonoyl‐GPE (18:0/20:4), α‐ketobutyrate, and 1‐palmitoyl‐GPE (16:0), mediated 26.0% of the association between current smoking and BMI. Conclusions This study cataloged plasma metabolites altered by cigarette smoking and identified five metabolites that partially mediated the association between current smoking and BMI.

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“…Due to 18:1 Lyso-PE abundance in brain tissues, Hisano et al demonstrated that Lyso-PEs encourage neurite outgrowth and defend against glutamate toxicity in cultured cortical neurons, thus suggesting the potential physiological function of 18:1 Lyso-PE in brain [ 81 ].…”

Section: Properties and Functions Of Phospholipids And Lysophospholip...mentioning

confidence: 99%

Emerging Role of Phospholipids and Lysophospholipids for Improving Brain Docosahexaenoic Acid as Potential Preventive and Therapeutic Strategies for Neurological Diseases

Hachem

Nacir

2022

IJMS

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Docosahexaenoic acid (DHA, 22:6n-3) is an omega-3 polyunsaturated fatty acid (PUFA) essential for neural development, learning, and vision. Although DHA can be provided to humans through nutrition and synthesized in vivo from its precursor alpha-linolenic acid (ALA, 18:3n-3), deficiencies in cerebral DHA level were associated with neurodegenerative diseases including Parkinson’s and Alzheimer’s diseases. The aim of this review was to develop a complete understanding of previous and current approaches and suggest future approaches to target the brain with DHA in different lipids’ forms for potential prevention and treatment of neurodegenerative diseases. Since glycerophospholipids (GPs) play a crucial role in DHA transport to the brain, we explored their biosynthesis and remodeling pathways with a focus on cerebral PUFA remodeling. Following this, we discussed the brain content and biological properties of phospholipids (PLs) and Lyso-PLs with omega-3 PUFA focusing on DHA’s beneficial effects in healthy conditions and brain disorders. We emphasized the cerebral accretion of DHA when esterified at sn-2 position of PLs and Lyso-PLs. Finally, we highlighted the importance of DHA-rich Lyso-PLs’ development for pharmaceutical applications since most commercially available DHA formulations are in the form of PLs or triglycerides, which are not the preferred transporter of DHA to the brain.

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Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades

Cited by 21 publications

References 27 publications

Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients

Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients

Examination of serum metabolome altered by cigarette smoking identifies novel metabolites mediating smoking‐BMI association

Emerging Role of Phospholipids and Lysophospholipids for Improving Brain Docosahexaenoic Acid as Potential Preventive and Therapeutic Strategies for Neurological Diseases

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