Structurally diverse biflavonoids from Dysosma versipellis and their bioactivity

Abstract

Five pairs of new biflavonoid enantiomers, (±)-dysosmabiflavonoids A–E (1–5), two new biflavonoids, dysosmabiflavonoids F–G (6–7), and four biosynthetically related precursors (8–11) were isolated from the roots and rhizomes of Dysosma versipellis.

Lignans from the Roots and Rhizomes of Dysosma versipellis and Their Cytotoxic Activities

“…Its dried roots and rhizomes (called “Bajiaolian” in Chinese) are mainly used for the treatment of parotitis [ 4 ], sore throat, snake bite, fall injury [ 5 ], epidemic encephalitis B [ 6 ], epidemic hemorrhagic fever, condyloma accuminata, and esophagus and breast carcinoma [ 7 ]. Previous phytochemical and pharmacological investigations revealed that D. versipellis is particularly rich in arylnaphthalide lignans and biflavonoids, and has attracted wide attention due to their cytotoxic and neuraminidase and acetylcholinesterase inhibitory properties [ 8 , 9 , 10 , 11 ]. In our search for cytotoxic natural products, one dibenzyltyrolactone lignan dysoslignan A ( 1 ), three new arylnaphthalide lignans dysoslignans B–C ( 2 – 4 ), along with fourteen known metabolites ( 5 – 18 ), were isolated from the roots and rhizomes of D. versipellis ( Figure 1 ).…”