Structurally diverse metabolites from the rare actinobacterium Saccharothrix xinjiangensis

Abstract

The bioassay-guided fractionation from cultures of the actinobacterium Saccharothrix xinjiangensis Act24Zk, collected from the Caspian Sea beach in Iran led to the isolation of three new compounds, caerulomycin M (1), saccharopyrone (2) and saccharonoic acid (3), together with the known compound, caerulomycin A (4). Their structures were elucidated from HRESIMS and 1D and 2D NMR data. Compound 2 displayed moderate cytotoxic activity against the human cervix carcinoma HeLa cells KB3.1 with an IC 50 value of 5.4 µM.

Marine natural products

“…25 New metabolites 80-82, 83, 84, 85 from Pseudomonas sp. were reported, 26 along with b-site amyloid precursor protein cleaving enzyme 1 (BACE 1) inhibitors saccharochlorines A 86 and B 87 from Saccharomonospora sp., 27 three new MNPs 88-90 from Saccharothrix xinjiangensis, 28 salinilactones D-H 91-95 from Salinispora sp., 29 a new aryl-containing polyketide 96 from Shewanella, 30 and from Streptomonospora specimens, litoralimycins A 97 and B 98, 31 and persiamycin A 99. 32 New Streptomyces-sourced MNPs included the antimicrobial adipostatins E-J 100-105, several of which inhibit coenzyme-A biosynthesis, 33 N-(12-methyl-10-oxobutyl)-L-tyrosine methyl ester 106, 34 antimicrobial lavandulylated avonoids 107 and 108 from a sponge-derived actinomycete, 35 meijiemycin 109, 36 and youssoufenes 110-114, that resulted from genetic manipulation of an aminotransferase family gene that activated production of these metabolites.…”

“…25 New metabolites 80–82 , 83 , 84 , 85 from Pseudomonas sp. were reported, 26 along with β-site amyloid precursor protein cleaving enzyme 1 (BACE 1) inhibitors saccharochlorines A 86 and B 87 from Saccharomonospora sp., 27 three new MNPs 88–90 from Saccharothrix xinjiangensis , 28 salinilactones D–H 91–95 from Salinispora sp., 29 a new aryl-containing polyketide 96 from Shewanella , 30 and from Streptomonospora specimens, litoralimycins A 97 and B 98 , 31 and persiamycin A 99 . 32…”

Bioprospecting of Soil-Derived Actinobacteria Along the Alar-Hotan Desert Highway in the Taklamakan Desert

“…Blast analysis based on the 16S rRNA gene sequence showed strain 16Sb2-4 shared the highest nucleotide sequence similarity (99.7%) with Saccharothrix xinjiangensis NBRC 101911 T , a strain that was previously isolated from Tianchi Lake, Xinjiang Uygur Autonomous Region, China (Hu et al, 2004). Strain of S. xinjiangensis has ever been reported to produce a range of bioactive compounds, such as the tianchimycins A and B (Wang et al, 2013), cyanogriside I and J, caerulomycin A and F (Lahoum et al, 2019), and caerulomycin M and saccharopyrone (Babadi et al, 2020). Taking these facts into consideration, strain 16Sb2-4 was prioritized to conduct a chemical analysis to gain deeper insights into its bioactive metabolites.…”

Natural Polypropionates in 1999–2020: An Overview of Chemical and Biological Diversity

“…In the bioassays, 7 was detected to show strong noncompetitive inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with the IC50 value of 4.0 µ M. A limestone soil-derived fungus Penicillium decumbens yielded an aliphatic acid 3,11-dihydroxy-6,8-dimethyldodecanoic acid ( 9) [11] which constructed a polypropionate fragment in the aliphatic chain. The bioassay-guided fractionation of the actinobacterium Saccharothrix xinjiangensis collected from Caspian Sea beach led to isolation of a N-containing polypropionate saccharonoic acid (10), which exhibited weak inhibitory activity against Mucor hiemalis and Candida albicans (IC50: 66.7 and 33.4 µ g/mL) [12]. Xylarinic acids A and B (11 and 12) were antifungal PPs from the fruiting body of Xylaria polymorpha [13].…”