2022
DOI: 10.1021/acs.biomac.2c00924
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Structurally Dynamic Gelatin-Based Hydrogels with Self-Healing, Shape Memory, and Cytocompatible Properties for 4D Printing

Abstract: Three-dimensional (3D) printable hydrogels with a shape memory effect have emerged as a new class of 4D printing materials recently and found wide applications in various fields. However, synergistically endowing such materials with good mechanical strength and biocompatibility for biomedical uses remains challenging. In this study, a series of multiresponsive hydrogels have been prepared through a dynamic covalent imine/Diels–Alder network from biocompatible starting materials of modified gelatin and poly(eth… Show more

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Cited by 17 publications
(7 citation statements)
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“…For example, traditional dressings attached to fingers do not fit to finger wounds well and easily deform and fall off due to the frequent bending of the fingers [36]. Injectable hydrogels can fill irregular wound areas and promote in situ tissue regeneration, and self-healing hydrogels can withstand external mechanical forces, thus extending their service life [37]. So, to promote a favorable environment for wound repair, functional hydrogel dressings should have improved resistance to mechanical injury and debridement capability [38] (Figure 3a).…”
Section: Dynamic Crosslinking Hydrogel Dressingsmentioning
confidence: 99%
“…For example, traditional dressings attached to fingers do not fit to finger wounds well and easily deform and fall off due to the frequent bending of the fingers [36]. Injectable hydrogels can fill irregular wound areas and promote in situ tissue regeneration, and self-healing hydrogels can withstand external mechanical forces, thus extending their service life [37]. So, to promote a favorable environment for wound repair, functional hydrogel dressings should have improved resistance to mechanical injury and debridement capability [38] (Figure 3a).…”
Section: Dynamic Crosslinking Hydrogel Dressingsmentioning
confidence: 99%
“…These biocompatible intelligent stents have the ability to reconfigure at 37 °C and reopen the blocked colon. PEG was also combined with gelatin and a hyperbranched triethoxysilane reagent (HPASi) to 3D print a thermoresponsive material that shows good biocompatibility, improved mechanical strength, and the ability to fold and unfold [ 158 ]. Indeed, the material was forced into a temporary shape of “V” with a folding angle of 171°, and after heating it, the hydrogel immediately recovered its original unfolded shape after a few seconds.…”
Section: Stimulus and Effect On Responsive Materialsmentioning
confidence: 99%
“…The double cross-linking in the hydrogel network contributed to the improvement in the mechanical properties and enabled the hydrogel to self-heal. Further, the temperature-responsive behavior of HPASi imparted shape memory to the hydrogel at around 65 °C . These studies thus provide new opportunities for the minimally invasive application of gelatin-based constructs as deployable or tissue-conforming structures that, once implanted in the body, can conform to a particular defect shape.…”
Section: Applicationsmentioning
confidence: 99%