“…26 When tested against the human glioblastoma cell line GaMG, the Pd (II) complex of 2 and its C-methyl analogue showed EC 50 values of 2.1 and 18.0 μM, while cisplatin and temozolomide showed EC 50 values of 3.4 and 57.01 μM. 27 Topoisomerase IIa was inhibited in vitro by 2 and its Cu(II) complex, whereas the Ni(II) complex was inert. 24 Herein, a series of Pd(II) complexes with N,N,S-tridentate thiosemicarbazone of the general formula [Pd(X)(N,N,S)] (X = Cl, Br, I, NCS and S-tetrazole) (Scheme 1) was tested against four malignant cell lines for their antiproliferative properties and the outcomes were compared to those seen in normal mouse splenocytes.…”