Structure–activity relationship for dihydromyricetin as a new natural antioxidant in polymer

Abstract

Dihydromyricetin (DMY), a natural product, was used as antioxidant in ethylene vinyl acetate copolymer (EVA) in our laboratory. Oxidation induction temperature (OIT) of EVA with the antioxidant of DMY and effect of pH on OIT was measured by means of differential scanning calorimeter (DSC). The mechanism on that antioxidation of DMY in EVA is produced on basis of determination of UV-Vis absorption, nuclear magnetic resonance (NMR) and the experiment of reacting the pyrogallic (PA) and DMY, respectively, with the DPPH. The result shows that the ortho-trihydroxyl group (B ring) in DMY has mainly antioxidative activity and hydroxyl group of 7-position (A ring) not only displayed reversibility to acidic or alkaline medium but also affected in some extent the antioxidative ability in EVA.

Dihydromyricetin suppresses inflammatory responses in vitro and in vivo through inhibition of IKKβ activity in macrophages

“…The chemical nature of these compounds depends on their structural class, degree of hydroxylation, other substitutions and conjugations, and degree of polymerization (Kumar and Pandey, ). It has been reported that the ortho‐trihydroxyl group in DMY has anti‐oxidative activity; while the hydroxyl group of DMY not only displays reversibility in acidic or alkaline medium but also affects the anti‐oxidative ability (Xin et al ., ). Previous studies showed that DMY has a variety of pharmacological activities, such as anti‐cancer, anti‐inflammation, and so on.…”

Determination of dihydromyricetin in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

“…And recent studies have demonstrated its pharmacological effects such as antioxidative, anti-inflammatory, antihypertensive, antiviral and hepatoprotective activities [2]. Dihydromyricetin (DMY), a dihydro flavonol compound found as the most abundant (approximately 30%) and bioactive constituent in vine tea, has been demonstrated to posses numerous pharmacological activities including anti-oxidant [3][4][5], anti-cancer [6][7][8], anti-inflammation [9], anti-hypertension [10], anti-fatigue [11], anti-alcoholic intoxication [12] and hepatoprotective effects [13].…”

Evaluation on Hepatoprotection of Dihydromyricetin in Acetaminophen-Induced Hepatotoxicity Based on Analysis of Inflammation and Apoptosis Mediated by PI3K/AKT Pathway

“…22 The ortho-trihydroxyl group (hydroxyl in the C-3’, 4’, and 5’ position) in B-ring of DHM has been demonstrated to have strong effect against free radicals and provide an antioxidant defense. 23, 24…”