Structure–Activity Relationship of Membrane-Targeting Cationic Ligands on a Silver Nanoparticle Surface in an Antibiotic-Resistant Antibacterial and Antibiofilm Activity Assay

Dai, Xiaomei; Chen, Xuelei; Zhao, Jing; Zhao, Yu; Guo, Qianqian; Zhang, Tianqi; Chu, Chunli; Zhang, Xinge; Li, Chaoxing

doi:10.1021/acsami.6b15821

Cited by 47 publications

(23 citation statements)

References 51 publications

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“…Therefore, the important point is to determine the removal ability of NPs to mature MRSA biofilms. We executed XTT quantitative determination assay, 29 SEM test, and LIVE/ DEAD BacLightTM Bacterial Viability Kits staining experiment, 30 respectively. As shown in Figure 4a-1, at 0.1 μ mol/ mL, the removal effect of CA-BBR NPs on mature biofilms was 64.22 ± 3.0%, while the removal rate of BBR group was only 32.98 ± 1.62%.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Self-Assemblies Based on Traditional Medicine Berberine and Cinnamic Acid for Adhesion-Induced Inhibition Multidrug-Resistant Staphylococcus aureus

Huang

Wang

et al. 2019

ACS Appl. Mater. Interfaces

133

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S. aureus is resistant to various first-line antibiotics, and seeking multifarious strategies aimed at effective control of antibiotic-resistant behavior is urgently needed. Here, we report a two-component directed self-assembly mode: the phytochemicals berberine and cinnamic acid can directly self-assemble into nanoparticles (NPs) displaying good bacteriostastic activity. Compared with several first-line antibiotics, the obtained nanostructures have a better inhibitory effect on multidrug-resistant S. aureus (MRSA) and stronger ability for biofilm removal. These qualities are attributed to the fact that organic assemblies can first spontaneously adhere to the surface of the bacteria, infiltrate into the cell, and then lead to converging attack against MRSA; thereafter, multipath bactericidal mechanisms of NPs on MRSA are found by both transcriptomic analysis and quantitative Polymerase Chain Reaction analysis. Moreover, when combined with spectral data and single crystal X-ray diffraction, the NPs’ self-assembly mechanism governed by hydrogen bonds and π–π stacking interactions is clearly elucidated. These non-covalent interactions induce the NPs’ formation of butterfly-like one-dimensional self-assembled units and finally layered three-dimensional spatial configuration. In addition, biocompatibility tests show that the NPs are nonhemolytic with little toxicity in vitro and in vivo. This directed self-assembly mode can offer a new perspective toward the design of biocompatible antimicrobial nanomedicines for clinical translation.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Self-Assemblies Based on Traditional Medicine Berberine and Cinnamic Acid for Adhesion-Induced Inhibition Multidrug-Resistant Staphylococcus aureus

Huang

Wang

et al. 2019

ACS Appl. Mater. Interfaces

133

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“…Previous reports showed that Ag nanocomposites (64 µg/mL) and cationic amphiphile could penetrate into the biofilms and eradicated them. Furthermore, AgNPs were reported to penetrate and disperse into biofilm matrixes and then deliver Ag + flux to the bacterial wall to eradicate the biofilms (Dai et al, 2017). Our results showed that Gram-positive bacteria were more resistant to AgPtNHs compared to Gram-negative bacteria.…”

Section: Discussionmentioning

confidence: 69%

Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics

et al. 2021

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Various bacterial pathogens are responsible for nosocomial infections resulting in critical pathophysiological conditions, mortality, and morbidity. Most of the bacterial infections are associated with biofilm formation, which is resistant to the available antimicrobial drugs. As a result, novel bactericidal agents need to be fabricated, which can effectively combat the biofilm-associated bacterial infections. Herein, for the first time we report the antimicrobial and antibiofilm properties of silver-platinum nanohybrids (AgPtNHs), silver nanoparticles (AgNPs), and platinum nanoparticles (PtNPs) against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The AgPtNHs were synthesized by a green route using Dioscorea bulbifera tuber extract at 100°C for 5 h. The AgPtNHs ranged in size from 20 to 80 nm, with an average of ∼59 nm. AgNPs, PtNPs, and AgPtNHs showed a zeta potential of −14.46, −1.09, and −11.39 mV, respectively. High antimicrobial activity was observed against P. aeruginosa and S. aureus and AgPtNHs exhibited potent antimicrobial synergy in combination with antibiotics such as streptomycin, rifampicin, chloramphenicol, novobiocin, and ampicillin up to variable degrees. Interestingly, AgPtNHs could inhibit bacterial biofilm formation significantly. Hence, co-administration of AgPtNHs and antibiotics may serve as a powerful strategy to treat bacterial infections.

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“…In the biocide‐releasing approach, the biocidal agents are preloaded or embedded and slowly released into the vicinity environment to kill bacteria. The widely used biocidal agents in literature include silver nanoparticles (AgNPs), antibiotics, and nitrogen oxide (NO), etc. In particular, the AgNPs have been applied to polymeric surface coatings as a potent and broad‐spectrum antibacterial agent, and the released silver ions can bind to the bacterial membrane and inactivate the proteins, which cause the lysis of bacterial cells at the vicinity .…”

Section: Monofunctional Antibacterial Materialsmentioning

confidence: 99%

Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens

Ding

Duan

Ding

et al. 2018

Adv Funct Materials

413

272

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Antibacterial materials that prevent bacterial infections and mitigate bacterial virulence have attracted great scientific interests. In recent decades, the bactericidal polymers have been presented as promising candidates to combat bacterial pathogens, mainly based on the construction of bactericidal cationic polymers, functionalization with biocidal agents, and formation of bacterial-repelling layers. However, these established strategies have inherent disadvantages because they often overlook important features such as their biocompatibility and biosafety, especially for biomedical applications. In recent years, many efforts have been made focusing on the development of multifunctional antibacterial materials to meet the elaborate requirements for medical devices and public hygiene products. Herein the recent advances in developing multifunctional materials for their antibacterial activities together with other functions including "kill-and-release" capability, hemocompatibility, cell proliferation promoting properties, and coagulation promoting ability for wound dressing are highlighted. In addition, the outlooks on the remaining challenges that should be addressed in the field of multifunctional antibacterial materials are also described.

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Structure–Activity Relationship of Membrane-Targeting Cationic Ligands on a Silver Nanoparticle Surface in an Antibiotic-Resistant Antibacterial and Antibiofilm Activity Assay

Cited by 47 publications

References 51 publications

Self-Assemblies Based on Traditional Medicine Berberine and Cinnamic Acid for Adhesion-Induced Inhibition Multidrug-Resistant Staphylococcus aureus

Self-Assemblies Based on Traditional Medicine Berberine and Cinnamic Acid for Adhesion-Induced Inhibition Multidrug-Resistant Staphylococcus aureus

Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics

Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens

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