1991
DOI: 10.1016/0742-8413(91)90236-m
|View full text |Cite
|
Sign up to set email alerts
|

Structure-activity relationship of philanthotoxins—i. pre- and postsynaptic inhibition of the locust neuromuscular transmission

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
16
0

Year Published

1992
1992
2014
2014

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 17 publications
(16 citation statements)
references
References 25 publications
0
16
0
Order By: Relevance
“…We reasoned that, if this model were correct, then mEPSPs and EPSPs should be inhibited to the same degree and over the same time course by blockers. To test this model, we employed the use-dependent GluR blocker Philanthotoxin-433 (PhTox) [68], which was demonstrated to produce stable inhibition of postsynaptic responses in the standard Drosophila larval NMJ preparation [9]. …”
Section: Resultsmentioning
confidence: 99%
“…We reasoned that, if this model were correct, then mEPSPs and EPSPs should be inhibited to the same degree and over the same time course by blockers. To test this model, we employed the use-dependent GluR blocker Philanthotoxin-433 (PhTox) [68], which was demonstrated to produce stable inhibition of postsynaptic responses in the standard Drosophila larval NMJ preparation [9]. …”
Section: Resultsmentioning
confidence: 99%
“…We restricted muscle move-played by calcium in these two compartments, i.e., synaptic vesicle release in the CX and postsynaptic integra-ments in the CX preparation by applying philanthotoxin, a blocker of muscular glutamate receptors that has been tion in the AL. The EYFP/ECFP ratio changes (0.6% Ϯ 0.06% mean Ϯ SEM, n ϭ 6 odorants, 1-5 averaged used in various insect preparations to block neuromuscular transmission [20,21]. The effects of philanthotoxin stimulations with each odorant in 10 animals, cf.…”
Section: With Anatomical Studies Showing That Projection Neurons Formmentioning
confidence: 99%
“…Anti-insect peptide and polyamine toxins are produced by a variety of organisms including fungi (4), scorpions (5-9), spiders (10)(11)(12)(13), wasps (14)(15)(16), mites (17,18) and bacteria (19)(20)(21). In general, these toxins bind to gating receptors and disturb ion flow across the cell membrane.…”
Section: Natural Toxinsmentioning
confidence: 99%
“…Numerous investigations are targeted at understanding toxin pharmacology and exploiting toxins as insect control agents. Synthetic analogues of delta-philanthotoxin have been designed, prepared, and used to investigate the pharmacology of the natural toxin (14,16). Studies on the omega-agatoxins have revealed a family of toxins with varying pharmacological properties (13), suggesting a complex array of toxins acting to block a variety of different calcium ion channels.…”
Section: Natural Toxinsmentioning
confidence: 99%