Structure-activity relationship of some analogues of gastrin and cholecystokinin on intestinal smooth muscle of the guinea-pig

Vizi, E.S.; Bertaccini, G.; Impicciatore, M; Mantovani, P.; Zséli, J; Knoll, J.

doi:10.1007/bf00500344

Cited by 23 publications

(3 citation statements)

References 21 publications

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“…Decreasing the intragastric pressure can be one of the reasons of this response (46,135). Gastrin also stimulates the intestinal motility (253,295). In many cases, gastrin appears to exert its effect upon the gastrointestinal motility acting directly on the smooth muscle (298).…”

Section: Gastrinmentioning

confidence: 99%

“…It was found that pentagastrin excited antral longitudinal muscle by the release of acetylcholine and directly stimulated the circular muscle layer (261). In the guinea pig ileum, it acted through the neural mechanisms since the motor response was abolished by tetrodotoxin and attenuated by atropine (295). Gastrin also disrupts the MMC pattern that was demonstrated clearly in the dog, although it does not seem to reproduce the fed pattern (68,163,304).…”

Section: Gastrinmentioning

confidence: 99%

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Importance of the enteric nervous system in the control of the migrating motility complex

Romanski

2017

Acta Physiol Hung

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The migrating motility complex (MMC), a cyclical phenomenon, represents rudimentary motility pattern in the gastrointestinal tract. The MMC is observed mostly in the stomach and gut of man and numerous animal species. It contains three or four phases, while its phase III is the most characteristic. The mechanisms controlling the pattern are unclear in part, although the neural control of the MMC seems crucial. The main goal of this article was to discuss the importance of intrinsic innervation of the gastrointestinal tract in MMC initiation, migration, and cessation to emphasize that various MMC-controlling mechanisms act through the enteric nervous system. Two main neural regions, central and peripheral, are able to initiate the MMC. However, central regulation of the MMC may require cooperation with the enteric nervous system. When central mechanisms are not active, the MMC can be initiated peripherally in any region of the small bowel. The enteric nervous system affects the MMC in response to the luminal stimuli which can contribute to the initiation and cessation of the cycle, and it may evoke irregular phasic contractions within the pattern. The hormonal regulators released from the endocrine cells may exert a modulatory effect upon the MMC mostly through the enteric nervous system. Their central action could also be considered. It can be concluded that the enteric nervous system is involved in the great majority of the MMC-controlling mechanisms.

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Section: Gastrinmentioning

confidence: 99%

Section: Gastrinmentioning

confidence: 99%

Importance of the enteric nervous system in the control of the migrating motility complex

Romanski

2017

Acta Physiol Hung

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“…It is of interest, in this respect, to mention that mRNA for CCK has been demonstrated in motor neurones in the spinal cord (20). In view of the fact that CCK potentiates the action of acetylcholine in contracting smooth muscles in the gastrointestinal tract of guinea pig (21) and in the sartorius muscle of frog (22), CCK may exert a similar potentiating function in the smooth and striated muscles of RAP children who are exposed to increased CCK concentrations. Whether or not the increased tension of certain striated muscles is in some way related to an enhanced production of CCK'within the motor neurones, or to the high concentrations of the peptides circulating, can of course not be established from the results obtained in the present study.…”

Section: Discussionmentioning

confidence: 99%

Elevated cholecystokinin concentrations in plasma in children with recurrent abdominal pain

Alfvén

Uvnäs‐Moberg

1993

Acta Paediatrica

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The objective of the present study was to measure plasma concentrations of the gastrointestinal hormones gastrin, somatostatin and cholecystokinin in plasma of children with recurrent abdominal pain, since these hormones affect gastrointestinal function. Forty-four children (7-16 years old) with recurrent abdominal pain and 36 control children (matched for age and sex) participated in the study. In a blood sample collected after an overnight fast, gastrin, somatostatin and cholecystokinin concentrations were measured by radioimmunoassay. The children with recurrent abdominal pain had higher plasma cholecystokinin levels (p < 0.001) than the controls. Whether or not this aberration is related to the clinical symptoms of children with recurrent abdominal pain remains to be established.

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Effects of Gastrointestinal Peptides on the Nervous System

Telegdy

1985

Neurochemical Systems

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Structure-activity relationship of some analogues of gastrin and cholecystokinin on intestinal smooth muscle of the guinea-pig

Cited by 23 publications

References 21 publications

Importance of the enteric nervous system in the control of the migrating motility complex

Importance of the enteric nervous system in the control of the migrating motility complex

Elevated cholecystokinin concentrations in plasma in children with recurrent abdominal pain

Effects of Gastrointestinal Peptides on the Nervous System

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