Structure–activity relationship study of thiosemicarbazones on an African trypanosome: Trypanosoma brucei brucei

Synthesis of a DNA-targeting nickel (II) complex with testosterone thiosemicarbazone which exhibits selective cytotoxicity towards human prostate cancer cells (LNCaP)

“…The occurrence of condensation was confirmed by the disappearance of parent bands at 1657 cm À1 , which is originally ascribed to the stretching vibrations of aldehyde v(C@O) of testosterone [37]. The formation of the Schiff base ligand was further confirmed as a strong new band attributed to azomethine v(C@N) linkage emerged at 1596 cm À1 [38,39]. In the meantime, the vibration at 3419 cm À1 assigned to hydroxyl (-OH) group of testosterone indicates that this functional group is preserved and not involved in the formation of ligand [40].…”

Anti‐proliferative activity of newly synthesized Cd(II), Cu(II), Zn(II),Ni(II), Co(II), VO(II), and Mn(II) complexes of 2‐((4,9‐dimethoxy‐5‐oxo‐5H‐furo[3,2‐g]chromen‐6‐yl)methylene) hydrazinecarbothioamide on three human cancer cells

“…These findings coincide with the presence of the thiosemicarbazone moiety. [61,62] The proton and carbon spectra demonstrated only one set of peaks, which indicate that the ligand has either an anti-isomer or a syn-isomer. Another possibility is the presence of an equilibrium state between the syn and anti-isomer, which is fast and the observed chemical shift is an average value.…”

5-Nitroisatin-derived thiosemicarbazones: potential antileishmanial agents

“…Negative controls received only medium, whereas the positive control contained varying concentrations of standard leishmanicidal compound, pentamidine. The plate was incubated at [21][22] C for 72 h. The culture was examined microscopically on an improved Neubauer counting chamber and IC 50 values of compounds were calculated by Software Ezfit 5.03 (Perella Scientific, Amherst, NH). All assays were performed in triplicate.…”

“…Thiosemicarbazones are an important class of organic compounds, which possesses a number of medicinal properties, including antibacterial, antifungal, antiprotozoal, antitumoral, antiviral and more particularly, the antileishmanial activities [8][9][10][11][12][13][14][15][16][17][18][19][20][21] . Isatin-derived thiosemicarbazones have also been found to possess a variety of biological activities, such as antimicrobial, antineoplastic, antiplasmodial and antiviral [22][23][24][25][26][27][28][29][30][31][32][33][34] .…”

“…7,8,[10][11][12][13][15][16][17][18][19]21,23,24,26,28 and 30 exhibited good to excellent antileishmanial activities with IC 50 values ranging from 0.44 AE 0.02 to 32.38 AE 0.66 mg/mL. Of these, 5, 7, 19 and 28 proved to be the most active antileishmanial agents, displaying activities with IC 50 values 1.78 AE 0.35, 0.44 AE 0.02, 1.91 AE 0.04 and 4.28 AE 0.75 mg/mL, respectively, which were even better than the standard drug, pentamidine (IC 50 ¼ 5.09 AE 0.04 mg/mL).…”