2024
DOI: 10.1002/cmdc.202400727
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Structure‐activity‐relationships of the Stability of Six Pentathiepins Towards Glutathione: Possible Correlations with Biological Activities

Martin Napierkowski,
Tom Schöne,
Siva Sankar Murthy Bandaru
et al.

Abstract: The biological properties of pentathiepins have been intensively studied in recent years. Although the proposed mechanism of action requires activation by intracellular thiols, the dependence of activity on the stability of pentathiepins towards glutathione (GSH) has not been directly investigated. Here, we determined the structure‐related stability of six different pentathiepins with four different scaffolds in the presence of GSH by using reversed‐phase high‐performance liquid chromatography (RP‐HPLC) and UV… Show more

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