Structure-activity study of acute neurobehavioral effects of cyclohexane, benzene, m-xylene, and toluene in rats

Armenta-Resendiz, Monserrat; Rı́os-Leal, Elvira; Rivera-García, María Teresa; López‐Rubalcava, Carolina; Cruz, Silvia L.

doi:10.1016/j.taap.2019.05.016

Cited by 20 publications

(8 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The calculated values were used to achieve toluene concentrations of 0, 1000, 2000, or 4000 ppm (see Figure 1B). The decision to use these concentrations was based on previous literature showing that toluene exposure at concentrations around 2000–4000 ppm produces behavioral effects in preclinical models similar to those observed in humans at abuse concentrations (Armenta‐Resendiz et al, 2019; Bowen & Balster, 1998; Bowen & McDonald, 2009; Kishi et al, 1988). The fan was then turned on to help to volatilize and circulate toluene vapor throughout the chamber.…”

Section: Methodsmentioning

confidence: 99%

Acute exposure to abuse‐like concentrations of toluene induces inflammation in mouse lungs and brain

Svenson

Davidson

Thakur

et al. 2022

J of Applied Toxicology

View full text Add to dashboard Cite

Toluene is an aromatic hydrocarbon commonly abused by young adolescents for its central nervous system depressant effects. Although toluene's pharmacological effects at high concentrations are relatively well-known, few studies have assessed toluene's effects on lung and brain tissues. The present study characterized the pathological effects of acute inhaled toluene exposure in the lungs and brains of male Swiss-Webster mice (N = 68). Using a static vapor exposure chamber, mice (PND 28) received a single 30-min toluene administration (0, 1000, 2000, or 4000 ppm). Lung and brain tissues were extracted 24-h post-exposure. Histology results revealed significant changes in the morphology of lung tissue (e.g., irregular cellular architecture) with the 2000-and 4000-ppm exposures expressing greater signs of pathology than control 0-ppm exposure. Markers of immune system activity (F4/80 and Ly-6G) and cellular proliferation (Ki-67) in the lung revealed no significant differences. Additionally, brain tissues were analyzed for changes of astrogliosis (glial fibrillary acidic protein [GFAP]) and oxidative stress (glutathione peroxidase [GPx]). GFAP showed increased astrogliosis in the striatum with 2000-ppm toluene showing significantly higher expression than control (p < 0.05) and a marginal effect in the hippocampus.No other markers showed significant changes. The increased signs of inflammation and cellular damage suggest that exposure to a single high concentration of toluene, typical of abuse, is capable of producing pathology in both lung and brain tissue.

show abstract

Section: Methodsmentioning

confidence: 99%

Acute exposure to abuse‐like concentrations of toluene induces inflammation in mouse lungs and brain

Svenson

Davidson

Thakur

et al. 2022

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

“…The main effect of inhaling o-xylene is depression of the central nervous system, with symptoms such as dizziness, headache or vomiting [ 56 , 57 ]. Chronic exposure may lead to insomnia, tremors, short-term memory loss and impaired concentration [ 58 , 59 ].…”

Section: Voc Removal Using Heterostructures/composites/doped Photomentioning

confidence: 99%

Volatile Organic Compounds (VOCs) Removal from Indoor Air by Heterostructures/Composites/Doped Photocatalysts: A Mini-Review

Eneşca

Cazan

2020

Nanomaterials

View full text Add to dashboard Cite

The impact of volatile organic compounds (VOCs) on indoor air quality and, furthermore, on human health is still a subject of research investigations considering the large increase in forms of cancer and related diseases. VOCs can be 10 times higher in indoor air concentrations then that of the outdoors, as a consequence of emissions from electronics, building materials and consumer goods. Direct transformation of VOCs in mineralization products seems to be an alternative to reduce indoor air contaminants. The advantage of photocatalysis implementation in indoor air treatment is given by the absence of additional chemicals (such as H2O2) and waste. The present mini-review presents a comparative study on VOCs photocatalytic removal considering the photocatalyst composition, morphology and specific surface. The sheet-like morphology seems to provide a higher number of active sites which may contribute to oxidative reactions. The insertion of materials able to increase light absorbance or to mediate the charge carrier’s transport will have a beneficial impact on the overall photocatalytic efficiency. Additionally, surface chemistry must be considered when developing photocatalysts for certain gas pollutants in order to favor molecule absorbance in the interfacial region. An energy consumption perspective is given based on the light intensity and irradiation period.

show abstract

“…In the workplace, they are mainly inhaled into the body in the form of vapor, causing great harm to human health. Long-term exposure can damage the nervous system, [1][2][3] reproductive system, [4][5][6][7][8] and hematopoietic system; [9][10][11][12] cause cytogenetic changes; [13][14][15][16] and even cause cancer. [17][18][19][20] In China, benzene poisoning has been the top three of chronic occupational poisoning in recent years.…”

Section: Introductionmentioning

confidence: 99%

“…In the workplace, they are mainly inhaled into the body in the form of vapor, causing great harm to human health. Long-term exposure can damage the nervous system, 1-3 reproductive system, 4-8 and hematopoietic system; 9-12 cause cytogenetic changes; 13-16 and even cause cancer. 17-20…”

Section: Introductionmentioning

confidence: 99%

Occupational Exposures and Health Risks of Benzene, Toluene, and Xylenes (BTX) in Automobile Repair Industry in Beijing City, China

Hao

Ren

Yang

et al. 2022

Asia Pac J Public Health

View full text Add to dashboard Cite

This study aimed to evaluate the occupational health risks of benzene, toluene, and xylenes (BTX) exposure in the automobile repair industry in Beijing city in China. The concentrations of BTX were monitored at 140 operating positions of 51 randomly selected automobile repair enterprises in 2018. Samples analysis showed that all monitoring concentrations were not higher than the occupational exposure limits. The long-term exposure concentration ranges of benzene, toluene, and xylenes were 0.1 to 0.3, 0.1 to 49.7, and 0.2 to 49.5 mg/m3, respectively. The short-term exposure concentration ranges of benzene, toluene, and xylenes were 0.1 to 0.3, 0.1 to 98.7, and 0.2 to 100.0 mg/m3, respectively. But assessment results revealed unneglectable occupational health risks, especially the combined health risks of BTX exposure. Thereafter, effective control and improvement measures were put forward, including strengthening the management of the production, sale, and use of vehicle paints and coatings; improving ventilation; and implementing hierarchical management measures for occupational health risks.

show abstract

Structure-activity study of acute neurobehavioral effects of cyclohexane, benzene, m-xylene, and toluene in rats

Cited by 20 publications

References 36 publications

Acute exposure to abuse‐like concentrations of toluene induces inflammation in mouse lungs and brain

Acute exposure to abuse‐like concentrations of toluene induces inflammation in mouse lungs and brain

Volatile Organic Compounds (VOCs) Removal from Indoor Air by Heterostructures/Composites/Doped Photocatalysts: A Mini-Review

Occupational Exposures and Health Risks of Benzene, Toluene, and Xylenes (BTX) in Automobile Repair Industry in Beijing City, China

Contact Info

Product

Resources

About