2019
DOI: 10.3390/molecules24244571
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Structure-Activity Study of an All-d Antimicrobial Octapeptide D2D

Abstract: The increasing emergence of multi-drug resistant bacteria is a serious threat to public health worldwide. Antimicrobial peptides have attracted attention as potential antibiotics since they are present in all multicellular organisms and act as a first line of defence against invading pathogens. We have previously identified a small all-d antimicrobial octapeptide amide kk(1-nal)fk(1-nal)k(nle)-NH 2 (D2D) with promising antimicrobial activity. In this work, we have performed a structure-activity relationship st… Show more

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Cited by 3 publications
(2 citation statements)
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“…In order to overcome these problems, there has been an increasing on the development of non-native sequences which retain all the advantages of parent peptide sequences, whilst overcoming rapid proteolytic degradation. The stability of promising synthetic sequences is typically improved by cyclization or insertion of non-proteinogenic building blocks, including D-amino acids, peptoids (N-substituted glycines) and other peptidomimetics such as α-peptide/β-peptides (Molchanova et al, 2017, Lone et al, 2019. Approaches to achieve stability typically rely on post-synthetic modification of traditional sequences or the synthesis of modified sequences which recapitulate the desirable properties whilst enhancing stability.…”
Section: Increasing In Vivo Longevitymentioning
confidence: 99%
See 1 more Smart Citation
“…In order to overcome these problems, there has been an increasing on the development of non-native sequences which retain all the advantages of parent peptide sequences, whilst overcoming rapid proteolytic degradation. The stability of promising synthetic sequences is typically improved by cyclization or insertion of non-proteinogenic building blocks, including D-amino acids, peptoids (N-substituted glycines) and other peptidomimetics such as α-peptide/β-peptides (Molchanova et al, 2017, Lone et al, 2019. Approaches to achieve stability typically rely on post-synthetic modification of traditional sequences or the synthesis of modified sequences which recapitulate the desirable properties whilst enhancing stability.…”
Section: Increasing In Vivo Longevitymentioning
confidence: 99%
“…It was postulated to have enhanced resistance to degradation owing to the use of non-native residues (Lone et al, 2019). Bactenecin is a 12-amino acid cyclic cationic antimicrobial peptide that contains one intramolecular disulfide bond.…”
Section: D-α-form Amino Acidsmentioning
confidence: 99%