The
formation of promising oil-in-water nanoemulsion suitable for
pesticide delivery has been achieved by using methyl laurate as oil
phase, and alkyl polyglycoside (APG) and polyoxyethylene 3-lauryl
ether (C12E3) as mixed surfactant. Effects of
APG and C12E3 mixing ratios, oil weight fraction,
and total surfactant concentration on droplet size and distribution
of the nanoemulsion were systematically investigated. Long-term stabilities
of the nanoemulsions prepared with various surfactant mixing ratios
were assessed by measuring droplet size at different time intervals;
the results indicated that the main driving force for droplet size
increase over time was Ostwald ripening. On this basis, a practical
water-insoluble pesticide β-cypermethrin (β-CP) was incorporated
into two optimized nanoemulsion systems to demonstrate potential applications.
The results of dynamic light scattering (DLS) and transmission electron
microscopy (TEM) measurements showed that the nanoemulsions had a
nearly monodisperse droplet size distribution (PDI < 0.2) and incorporation
of β-CP had no notable effect on the size and stability of the nanoemulsions. For consideration
of practical application, dilution stability and spreading properties
of the pesticide-loaded nanoemulsion were studied by DLS, contact
angle, and dynamic surface tension, respectively. The nanoemulsion
was still homogeneous after dilution, although destabilization in
droplet size was observed by DLS. The results of contact angle and
dynamic surface tension demonstrated the excellent spreading performance
of the optimized nanoemulsion.