Structure and analgesic properties of layered double hydroxides intercalated with low amounts of ibuprofen

Abstract

Ibuprofen‐intercalated layered double hydroxides (LDH‐IBU) have been successfully synthesized via a coprecipitation method with a nominal [Al3+]/[Mg2+] ratio of 0.5 and a variable molar IBU/([Al3+]+[Mg2+]) ratio of 0, 0.15, 0.18, 0.24, 0.36, and 0.72. After an accurate determination of the composition, the nature of the intercalated species and the effective intercalation yield from NO3− to IBU, it is shown that the synthesis route used allows a good control of the quantity of intercalated IBU within the LDH framework. This results in different samples with full or partial IBU intercalation in the interlayer space in exchange of nitrate anions. The analysis of the X‐ray diffraction basal reflections reveals that the intercalation of IBU in the framework only increases the basal distances with no alteration of the brucite‐type layers. Also, a computational study used to model the positions and shapes of the basal reflections showed that the structure of the nonfully intercalated compounds follows a random interstratification scheme. Finally, three samples ranging from slightly to fully IBU‐intercalated galleries were selected for preliminary in vivo assays. These tests showed a strong tendency that after 24 hours the low yield of IBU‐intercalated compounds are almost as efficient as the fully intercalated sample.

Layered double hydroxide–indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases

“…The morphology observed in pure LDH and LDH-INDO are similar to what was previously seen in Magnesium and aluminum based LDH clays, usually platelets-like morphology, as shown in Figure 4 (Sousa et al, 2017;Tao et al, 2006). The FE-SEM images of LDH suggest a particle size of about 100 at 160 nm and a thickness of a few nanometers (Figure 4A).…”

“…The indomethacin (INDO) quantification into LDH (MgAl-NO3) was determined by ultraviolet-visible absorbance (UV-Vis) using Shimadzu UV-2600 model, as described in our previous work (Sousa et al, 2017). Initially, 0.5 ml of ethanol and 0.5 ml of 0.1 M HCl solution were used to dissolve a milligram of the LDH-INDO complex then diluted with phosphate buffer solution (PBS) at pH 7.4 ± 0.02 in a 10 ml volumetric flask.…”

“…The in vitro release of INDO was performed following the method described by Sousa et al (2017) 10 mg of the LDH-INDO was immersed in 100 ml of a phosphate buffer solution (PBS) at pH 4.8 ± 0.02 and 7.4 ± 0.02 with mild shaking at 150 rpm and temperature maintained at 37 ± 0.5 °C. An aliquot of 5 ml was taken from the suspension and immediately replaced by an equal volume of PBS at 37 ± 0.5 °C to keep the temperature and volume constant.…”

New nanocarried phenobarbital formulation: Maintains better control of pentylenetetrazole-Induced seizures

“…In the last decades, various nanomaterials have been studied as a perspective class for drug delivery systems [ [1] , [2] , [3] , [4] , [5] ]. Among them, layered double hydroxides (LDHs) has attracted the attention due to its ion exchange ability, more stable structure, good biocompatibility and large drug carrying, in addition to drug release [ [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] ]. LDHs have also been largely reported for biological and other broad applications [ [17] , [18] , [19] , [20] , [21] ].…”

“…LDHs have also been largely reported for biological and other broad applications [ [17] , [18] , [19] , [20] , [21] ]. Most studies have focused on the development of nanosystem formulations for cancer treatment [ 10 , 22 , 23 ], inflammatory [ 7 , 15 , 24 ], cardiovascular and the fight against Acquired Immunodeficiency Syndrome virus (AIDS) [ [25] , [26] , [27] ]. LDHs can be described by the general formula [ 28 , 29 ], where and are respectively divalent and trivalent cations, represents the interlayer charge of the ionic molecule, is the molar fraction of the trivalent cation.…”