Structure and antibacterial properties of Ag and N doped titanium dioxide coatings containing Ti2.85O4N phase, prepared by magnetron sputtering and annealing

Dziedzic, Andrzej; Bochnowski, W.; Adamiak, S.; Szyller, Łukasz; Cebulski, J.; Virt, І. S.; Kus‐Liśkiewicz, Małgorzata; Marzec, Mateusz; Потера, П.; Żaczek, Anna; Zdeb, B.

doi:10.1016/j.surfcoat.2020.125844

Cited by 14 publications

(1 citation statement)

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“…What more, due to antibacterial effect these materials may be useful for various biomedical application, i.e. as antimicrobial and disinfect agent, or to prepare the antiseptic layers 85 – 87 . Simultaneously, the same nanomaterial, depends on the concentration used, could be a great platform for targeted drug delivery, as well as to combat with cancer cells 88 , 89 .…”

Section: Resultsmentioning

confidence: 99%

Noncytotoxic silver nanoparticles as a new antimicrobial strategy

Skóra

Krajewska

Nowak

et al. 2021

Sci Rep

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Drug-resistance of bacteria is an ongoing problem in hospital treatment. The main mechanism of bacterial virulency in human infections is based on their adhesion ability and biofilm formation. Many approaches have been invented to overcome this problem, i.e. treatment with antibacterial biomolecules, which have some limitations e.g. enzymatic degradation and short shelf stability. Silver nanoparticles (AgNPs) may be alternative to these strategies due to their unique and high antibacterial properties. Herein, we report on yeast Saccharomyces cerevisiae extracellular-based synthesis of AgNPs. Transmission electron microscopy (TEM) revealed the morphology and structure of the metallic nanoparticles, which showed a uniform distribution and good colloid stability, measured by hydrodynamic light scattering (DLS). The energy dispersive X-ray spectroscopy (EDS) of NPs confirms the presence of silver and showed that sulfur-rich compounds act as a capping agent being adsorbed on the surface of AgNPs. Antimicrobial tests showed that AgNPs inhibit the bacteria growth, while have no impact on fungi growth. Moreover, tested NPs was characterized by high inhibitory potential of bacteria biofilm formation but also eradication of established biofilms. The cytotoxic effect of the NPs on four mammalian normal and cancer cell lines was tested through the metabolic activity, cell viability and wound-healing assays. Last, but not least, ability to deep penetration of the silver colloid to the root canal was imaged by scanning electron microscopy (SEM) to show its potential as the material for root-end filling.

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