Structure and biocompatibility of poly(vinyl alcohol)-based and agarose-based monolithic composites with embedded divinylbenzene-styrene polymeric particles

Berezhna, Lydia G; Ivanov, Alexander E.; Leistner, André; Lehmann, Anke; Viloria-Cols, Maria; Jungvid, Hans

doi:10.1186/2194-0517-2-4

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…They assessed the biocompatibility of composite cryogels by estimation of the C5a fragment of complement in the serum sample and concentration of fibrinogen in the blood plasma which contacted the composite cryogels. A time-dependent generation of C5a fragment indicated weak activation of the complement system [87].…”

Section: Composite Cryogels As Versatile Tools For Biomedical Applmentioning

confidence: 99%

Supermacroporous Composite Cryogels in Biomedical Applications

Saylan

Denizli

2019

Gels

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Supermacroporous gels, called cryogels, are unique scaffolds that can be prepared by polymerization of monomer solution under sub-zero temperatures. They are widely used in many applications and have significant potential biomaterials, especially for biomedical applications due to their inherent interconnected supermacroporous structures and easy formation of composite polymers in comparison to other porous polymer synthesis techniques. This review highlights the fundamentals of supermacroporous cryogels and composite cryogels, and then comprehensively summarizes recent studies in preparation, functionalization, and utilization with mechanical, biological and physicochemical features, according to the biomedical applications. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable supermacroporous composite cryogels.

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Section: Composite Cryogels As Versatile Tools For Biomedical Applmentioning

confidence: 99%

Supermacroporous Composite Cryogels in Biomedical Applications

Saylan

Denizli

2019

Gels

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“…This idea of incorporating particles into hydrogel for detoxification purposes has been demonstrated by early studies454647. We propose to shape the PEG matrix encapsulated with PDA nanoparticles into a designer structure using 3D printing, a disruptive technology that is finding promising applications in creating unique 3D devices and tissue constructs4849.…”

Section: Discussionmentioning

confidence: 99%

Bio-inspired detoxification using 3D-printed hydrogel nanocomposites

Gou¹,

et al. 2014

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Rationally designed nanoparticles that can bind toxins show great promise for detoxification. However, the conventional intravenous administration of nanoparticles for detoxification often leads to nanoparticle accumulation in the liver, posing a risk of secondary poisoning especially in liver-failure patients. Here we present a liver-inspired three-dimensional (3D) detoxification device. This device is created by 3D printing of designer hydrogels with functional polydiacetylene nanoparticles installed in the hydrogel matrix. The nanoparticles can attract, capture and sense toxins, while the 3D matrix with a modified liver lobule microstructure allows toxins to be trapped efficiently. Our results show that the toxin solution completely loses its virulence after treatment using this biomimetic detoxification device. This work provides a proof-of-concept of detoxification by a 3D-printed biomimetic nanocomposite construct in hydrogel, and could lead to the development of alternative detoxification platforms.

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“…Several types of monomers are used to produce these cryogels all with similar properties. Commonly used monomers are acrylamide , 2‐hydroxyethyl methacrylate , and poly(vinylalcohol) . On the other hand, a disadvantage of the cryogel is its low adsorption capacity .…”

Section: Introductionmentioning

confidence: 99%

“…Attempts to increase the surface area and binding capacity are done by e.g. bead embedding , molecular imprinting , or increasing the bulk volume of the cryogel .…”

Section: Introductionmentioning

confidence: 99%

Development and screening of epoxy‐spacer‐phage cryogels for affinity chromatography: Enhancing the binding capacity

Noppe

Deckmyn

2017

J of Separation Science

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Macroporous epoxy cryogels can be used as an alternative for classical matrices in affinity chromatography. Due to the structural properties of cryogels, with pores of up to 100 μm, crude samples can be processed at high speed without previous manipulations such as clarification or centrifugation. Also, we previously used a peptide-expressing M13 bacteriophage as an affinity ligand. These ligands show high specificity toward the target to be purified. Combination of both, leads to a relative cost-effective one-step chromatographic set-up delivering a high purity sample (>95%), however, so far with limited capacity. To increase the binding capacity of the affinity columns, we now inserted spacers between the chromatographic matrix and the phage ligand. Both linear spacers, di-amino-alkanes (C -C ), and branched polyethyleneimine spacers with different molecular weights (800 Da-10 kDa) were analyzed. Two types of peptide expressing phage ligands, a linear 15-mer and a cyclic 6-mer, were used for screening. Up to a tenfold increase in binding capacity was observed depending on the combination of phage ligand and spacer type.

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Structure and biocompatibility of poly(vinyl alcohol)-based and agarose-based monolithic composites with embedded divinylbenzene-styrene polymeric particles

Cited by 7 publications

References 30 publications

Supermacroporous Composite Cryogels in Biomedical Applications

Supermacroporous Composite Cryogels in Biomedical Applications

Bio-inspired detoxification using 3D-printed hydrogel nanocomposites

Development and screening of epoxy‐spacer‐phage cryogels for affinity chromatography: Enhancing the binding capacity

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