Structure and Cellular Localization of Secretory IgA

O'Daly, José A.; Cebra, John J.

doi:10.1016/b978-0-08-013348-5.50030-2

Cited by 11 publications

(28 citation statements)

References 14 publications

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“…Secretory component is manufactured in secretory epithelial cells (MartinezTello et al 1968;O'Daly and Cebra 1968;Tourville et al 1970) and is bound to dimeric IgA by covalent and disulfide bonds during passage of the immunoglobulin across the epithelial cell (Heremans and Vaerman 1971). There have been numer()us suggestions that secretory component serves a receptor and transport function in collecting IgA and ferrying it from the basal membrane of the epithelial cell to the lumen.…”

Section: Secretion Of Locally Synthesized Antibodymentioning

confidence: 99%

Immunological Functions of the Mammary Gland and Its Secretion-Comparative Review

Dl¹

1980

Aust. Jnl. Of Bio. Sci.

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The mammary gland performs vitally important immunological roles, both in providing passive immune protection to the suckling infant and in immunological defence of its own tissues against infection with microorganisms. These immunological functions differ greatly between species of mammals in both nature and magnitude. In ungulates the mammary gland is singularly responsible for transfer of immunoglobulin (IgG) from mother to young. This process is dependent on a highly selective mechanism which results in the transport of blood-borne IgG molecules across secretory epithelial cells of the colostrum-forming mammary gland and into secretion. Upon ingestion of colostrum by the young ungulate this immunoglobulin is absorbed across the wall of the small intestine and thence into the bloodstream.In other species, including rodents and primates, there is a well-developed local IgA system operating in the mammary gland. In this situation, plasma cells located near the basal membranes of secretory epithelial cells secrete IgA which passes through the epithelial cells and into colostrum or milk. In these species the IgA in mammary secretions is not absorbed into the circulation of the suckling infant; because of its unique property of resisting proteolytic degradation, it may mediate a local protective role in the lumen of the intestine of the suckling infant.Specific immunological protection of mammary tissue may be mediated through blood-derived antibody (particularly IgG), locally synthesized antibody (particularly IgA) or phagocytic cells. Neutrophils arrive in mammary tissue and secretions in very large numbers following bacterial invasion of the gland. It has been established recently that these cells carry cytophilic antibody on their cell membrane. This cytophilic antibody can play an important functional role in enhancing the phagocytic capacity of neutrophils in the mammary gland.

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Section: Secretion Of Locally Synthesized Antibodymentioning

confidence: 99%

Immunological Functions of the Mammary Gland and Its Secretion-Comparative Review

Dl¹

1980

Aust. Jnl. Of Bio. Sci.

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“…In addition, most of the donor immunocytes in any given crosssection were producing IgA (~Figs. [1][2][3][4]. Donor cells producing IgG were also found, but at a much lower frequency.…”

Section: Distribution Of Iga-and Igg-producing Donor Cells In Cryostamentioning

confidence: 99%

PEYER'S PATCHES: AN ENRICHED SOURCE OF PRECURSORS FOR IGA-PRODUCING IMMUNOCYTES IN THE RABBIT

Craig

Cebra

1971

The Journal of Experimental Medicine

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700

262

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The secretory glands of many mammals are known to produce large amounts of a gamma-A immunoglobulin (sIgA) which is shed into the external secretions. Immunofluorescent staining of the subepithelial mucosa of many types of secretory glands and tissues (e.g. mammary, lacrimal, salivary, bronchial, and nasal as well as the lamina propria along the whole of the gastrointestinal tract) has shown that the majority of all immunoglobulin-producing cells in these sites are producing IgA (1).In particular, it has been reported (2, 3) that in the rabbit approximately 80% of all immunoglobulin-producing cells in the lamina propria of the small intestine stain specifically for the alpha chain of IgA. In contrast, only 8-10% of all similar cells in the spleen and lymph nodes contain this class of immunoglobulin. The observed predominance of IgA-producing cells in the lamina propria of the intestine suggested to us the possibility that the gut of a normal animal might contain a population of precursor cells which would be capable of proliferating and giving rise to IgA-producing cells.By using a method of analysis developed by Frensdorff et al. (4,5) in which cell transfer and subsequent quantitation of immunocytes by immunofluorescence is used to assess the proliferative and differentiative potential of rabbit lymphoid cells in irradiated allogeneic hosts, we were able to show that the Peyer's patches contain an enriched source of precursors for IgA-producing cells. These cells proliferate both in the spleen and in the intestinal lamina propria and give rise to immunoglobulin-producing cells, most of which make IgA. Materials and MethodsAnlmal~.--Male rabbits, weighing between 5 and 6 lb., were obtained from B and H Rabbitry (Rockville, Md.). Approximately 96% of the rabbits we have obtained from this rabbitry were homozygous for the b4 allotypic marker, an antigenic marker on the kappa *

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“…Thus, presumably, two T chains per molecule are required to account for the overall MW of the intact secretory IgA (46). Some of the characteristics of rabbit secretory IgA are as follows (10,11,46): sedimentation coefficient, 10.8S; extinction coefficient (0.1 N NaOH), 13.5; hexose content (1:1 ratio of galactose to mannose), 3.2%; hexosamine content, 3.2%; sulfhydral content, 0.75 mole/170,000 g; serum concentration (adult), 180 ,gg/ml. MW of secretory IgA is 385,000; a chain, 64,000; L chain, 22,500; T chain, 21,600.…”

Section: Gross Molecular Formmentioning

confidence: 99%

Immunoglobulins and immunocytes.

Cebra¹

1969

Bacteriological Reviews

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Structure and Cellular Localization of Secretory IgA

Cited by 11 publications

References 14 publications

Immunological Functions of the Mammary Gland and Its Secretion-Comparative Review

Immunological Functions of the Mammary Gland and Its Secretion-Comparative Review

PEYER'S PATCHES: AN ENRICHED SOURCE OF PRECURSORS FOR IGA-PRODUCING IMMUNOCYTES IN THE RABBIT

Immunoglobulins and immunocytes.

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