Structure and design of polymeric surfactant-based drug delivery systems

Biodegradable Self-Assembling PEG-Copolymer as Vehicle for Poorly Water-Soluble Drugs

“…The method of preparation can also affect drug loading efficiency (for review, see Refs. 3,11). Rather low drug content (2% to 4% w/w) were achieved compared to the drug content in micelles formed from other PEGpolyesters.…”

“…However, the incorporation of drugs into diblock polymeric micelles is usually a long and multi-step procedure, which often requires the use of organic solvents (for reviews, see Refs. 2,3,[10][11][12][13][14]. There are various methods for the incorporation of drugs in the blockcopolymer micelles.…”

Hydroxypropyl-β-Cyclodextrin Copolymers and Their Nanoparticles as Doxorubicin Delivery System

“…It was clearly shown that micelles possess a number of unbeatable advantages as potential drug delivery systems for poorly soluble pharmaceuticals. 1,2 The hydrophobic core of micelles may be used as a cargo space for encapsulation of a variety of sparingly soluble therapeutic and diagnostic agents. Such encapsulation substantially increases their bioavailability, protects them from destructive factors upon parenteral administration, and beneficially modifies their pharmacokinetics and biodistribution.…”

“…Such encapsulation substantially increases their bioavailability, protects them from destructive factors upon parenteral administration, and beneficially modifies their pharmacokinetics and biodistribution. 1,2 The size of micelles permits their extravasation and accumulation in a variety of pathological sites, where the permeability of the vascular endothelium is increased, such as infarct zones and tumors. [3][4][5][6] This fact provides a unique opportunity for physiology-based targeting of drugs and/ or drug-loaded pharmaceutical carriers, such as micelles, to these pathological areas via the enhanced permeability and retention (EPR; or "passive" targeting) effect.…”

“…In vivo, this may result in micelle collapse in a large blood volume with a subsequent precipitation of the encapsulated drug, that is, sharp decrease in its bioavailability and ability to penetrate biological barriers. 2 As has been known, in aqueous media, certain polyethylene glycol-phosphatidylethanolamine (PEG-PE) conjugates form very stable micelles. The PEG-based corona makes these micelles longcirculating, whereas the lipid hydrophobic core may be used as a cargo space for poorly soluble compounds, including many anticancer drugs.…”