Structure and development of the human hippocampus in prenatal ontogenesis

Bogolepova, I. N.

doi:10.1007/bf01125664

Cited by 8 publications

(4 citation statements)

References 13 publications

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“…In a more recent volumetric investigation2 of the hippocampal formation, Kretschmann et al (1986) reported that the human hippocampus is about 40% mature by birth, 50% mature by 1-1.5 months, and completely mature by 15 months of age. The dentate gyrus shows even earlier maturation in the human than in the monkey (Conel, 1939;Rakic and Sidman, 1968;Bogolepova, 1970;Rakic, 1973, 1982;Kostovic, 1975;Purpura, 1975aPurpura, , 1975b. Indeed, Purpura (1975a) demonstrated that granule cells were already present in a 35-week postconception preterm infant, and, in terms of dendritic growth and development of pyramidal neurons, presented evidence that the hippocampus matures earlier and faster prenatally than the visual cortex (Purpura, 1975b).…”

Section: Maturation Of the Hippocampal Formationmentioning

confidence: 99%

Maturation of medial temporal lobe memory functions in rodents, monkeys, and humans

Bachevalier¹,

Beauregard²

1993

Hippocampus

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Section: Maturation Of the Hippocampal Formationmentioning

confidence: 99%

Maturation of medial temporal lobe memory functions in rodents, monkeys, and humans

Bachevalier¹,

Beauregard²

1993

Hippocampus

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“…For example, it has been estimated that about 80% of granule cells in the rhesus monkey are generated before birth (Rakic and Nowakowski,198 1). Although we do not have similar 3H-TdR autoradiographic data, comparative histological and cytological analyses indicate that the dentate gyrus in humans also has a large prenatal phase of neurogenesis (Rakic and Sidman, 1968;Bogolepova, 1970;Rakic, 1973, 1982;Kostovic, 1975;Purpura, 1975).…”

Section: Electron Microscopy and Immunocytochemistrymentioning

confidence: 99%

Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey

1988

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The nature of proliferative cells in the subgranular zone (SGZ) of the hippocampal region and the fate of their progeny was analyzed by 3H- thymidine (3H-TdR) autoradiography combined with immunocytochemistry at the light and electron microscopic levels in 18 rhesus monkeys ranging in age from late gestation to 17 years. Our analysis indicates that, during the last quarter of gestation and the first 3 postnatal months, the SGZ produces both glial and neuronal cells. These 2 major classes of cells originate from the 2 precursor lines and, following their mitotic division, migrate to the granular layer. During the juvenile period (4–6 months of age), neuronal production tapers off and most postmitotic cells remaining within the SGZ differentiate into glial elements. In postpubertal animals (3 years and older), the 3H-TdR- labeled cells in the dentate gyrus belong to several non-neuronal classes. The largest group was immunoreactive to the glial fibrillary acidic protein (GFAP) at both the light and electron microscopic levels, indicating their astrocytic nature. The remaining 3H-TdR- labeled, GFAP-negative cells had ultra-structural characteristics of either microglia, oligodendroglia, or their progenitory stem cells. Therefore, there is a continuing addition and/or turnover of the glial cells in the dentate gyrus of sexually mature monkeys, but, in contrast to the massive neurogenesis reported in adult rodents, the production of new neurons could not be detected after puberty. The significance of a stable population of neurons in the hippocampal formation of mature primates is discussed in relation to its possible function in memory.

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“…Although highly connected to the amygdala [127], it has been claimed that the "removal of the hippocampus does not affect olfaction or taste" ( [11], p. 857). However, "evidence exists for input to the hippocampus from the amygdaloid complex, implicating it in the processing of emotional information and thus indirectly in interoceptive processes" ( [18], p. 120).…”

Section: Rationale For the Interest In Hippocampus In Relation To Foomentioning

confidence: 99%

The anterior medial temporal lobes: Their role in food intake and body weight regulation

Coppin

2016

Physiology & Behavior

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• The amygdala and hippocampus play a major role in food intake and weight regulation.• These functions are far less known to cognitive and affective scientists.• This review uniquely expands on the interactions between these two brain structures. a b s t r a c t a r t i c l e i n f o The anterior medial temporal lobes are one of the most studied parts of the brain. Classically, their two main structures -the amygdalae and the hippocampi -have been linked to key cognitive and affective functions, related in particular to learning and memory. Based on abundant evidence, we will argue for an alternative but complementary point of view: they may also play a major role in food intake and body weight regulation. First, an overview is given of early clinical evidence in this line of thought. Subsequently, empirical evidence is presented on how food intake, including in the extreme case of obesity, may relate to amygdalian and hippocampal functioning. The focus is on the amygdala's role in processing the relevance of food stimuli, cue-induced feeding, and stress-induced eating and on the hippocampus' involvement in the use of interoceptive signals of hunger and satiety, as well as memory and inhibitory processes related to food intake. Additionally, an elaboration takes place on possible reciprocal links between food intake, body weight, and amygdala and hippocampus functioning. Finally, issues that seemed particularly critical for future research in the field are discussed.

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Structure and development of the human hippocampus in prenatal ontogenesis

Cited by 8 publications

References 13 publications

Maturation of medial temporal lobe memory functions in rodents, monkeys, and humans

Maturation of medial temporal lobe memory functions in rodents, monkeys, and humans

Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey

The anterior medial temporal lobes: Their role in food intake and body weight regulation

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