Structure and function of Pacinian corpuscles

Ilʹinskiĭ, O. B.; Volkova, N. K.; Cherepnov, V. L.

doi:10.1007/bf01124145

Cited by 5 publications

(3 citation statements)

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“…The same study also showed that a decapsulated terminal reversed the polarity of its neural response when compressed horizontally to the nerve or vertically to the nerve and proposed that the bilateral arrangement of cells around the terminal is responsible for changing how compression is transmitted to the neurite in these different orientations. It has also been shown [ 37 ] that compression of an intact PC along its long axis requires a much stronger stimulus to cause depolarization than that required in compression along the short axis. The current study models the transmission of mechanical stimuli through the lamellae to the neurite, and showed differences with PC orientation, but does not address the electrophysiological effects reported by others [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has also been shown [ 37 ] that compression of an intact PC along its long axis requires a much stronger stimulus to cause depolarization than that required in compression along the short axis. The current study models the transmission of mechanical stimuli through the lamellae to the neurite, and showed differences with PC orientation, but does not address the electrophysiological effects reported by others [ 36 , 37 ]. A combined model (cf.…”

Section: Discussionmentioning

confidence: 99%

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Multiscale Mechanical Model of the Pacinian Corpuscle Shows Depth and Anisotropy Contribute to the Receptor’s Characteristic Response to Indentation

2015

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Cutaneous mechanoreceptors transduce different tactile stimuli into neural signals that produce distinct sensations of touch. The Pacinian corpuscle (PC), a cutaneous mechanoreceptor located deep within the dermis of the skin, detects high frequency vibrations that occur within its large receptive field. The PC is comprised of lamellae that surround the nerve fiber at its core. We hypothesized that a layered, anisotropic structure, embedded deep within the skin, would produce the nonlinear strain transmission and low spatial sensitivity characteristic of the PC. A multiscale finite-element model was used to model the equilibrium response of the PC to indentation. The first simulation considered an isolated PC with fiber networks aligned with the PC’s surface. The PC was subjected to a 10 μm indentation by a 250 μm diameter indenter. The multiscale model captured the nonlinear strain transmission through the PC, predicting decreased compressive strain with proximity to the receptor’s core, as seen experimentally by others. The second set of simulations considered a single PC embedded epidermally (shallow) or dermally (deep) to model the PC’s location within the skin. The embedded models were subjected to 10 μm indentations at a series of locations on the surface of the skin. Strain along the long axis of the PC was calculated after indentation to simulate stretch along the nerve fiber at the center of the PC. Receptive fields for the epidermis and dermis models were constructed by mapping the long-axis strain after indentation at each point on the surface of the skin mesh. The dermis model resulted in a larger receptive field, as the calculated strain showed less indenter location dependence than in the epidermis model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Multiscale Mechanical Model of the Pacinian Corpuscle Shows Depth and Anisotropy Contribute to the Receptor’s Characteristic Response to Indentation

2015

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“…When a limb flexes, an artery in the limb is bent and compressed (MacTaggart et al, 2014) thereby causing a turbulent blood flow in the vessel around the bending portion (Wood et al, 2006), which in turn may cause an increase or decrease of the pulsative blood movement. The threshold of PCs has been reported to increase when the receptor is stimulated along the vertical axis and to decrease when the PC is stimulated along the transverse axis of the nerve ending (Il'inskii et al, 1968). Thus, it is expected that the lamellar sensory corpuscles that exist parallel to blood vessels respond effectively to mechanical stimulation from blood vessels along the transverse axes of lamellar sensory corpuscles.…”

Section: Discussionmentioning

confidence: 99%

Relationship between lamellar sensory corpuscles distributed along the upper arm’s deep arteries and pulsating sensation of blood vessels

et al. 2021

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Vibration is detected by mechanoreceptors, including Pacinian corpuscles (PCs), which are widely distributed in the human body including the adventitia of large blood vessels. Although the distribution of PCs around large limb vessels has been previously reported, there remains no consensus on their distribution in the adventitia of the human deep blood vessels in the upper arm. In addition, the physiological functions of PCs located around the deep limb blood vessels remain largely unknown. This study aimed to elucidate detailed anatomical features and physiological function of lamellar sensory corpuscles structurally identified as PCs using the immunohistochemical methods around the deep vessels in the upper arm. We identified PCs in the connective tissue adjacent to the deep vessels in the upper arm using histological analysis and confirmed that PCs are located in the vascular sheath of the artery and its accompanying vein as well as in the connective tissue surrounding the vascular sheath and nerves. PCs were densely distributed on the distal side of deep vessels near the elbow. We also examined the relationship between vascular sound and pulsating sensation to evaluate the PCs functions around deep arteries and veins and found that the vascular sound made by pressing the brachial arteries in the upper arm was associated with the pulsating sensation of the examinee. Our results suggest that PCs, around deep vessels, function as bathyesthesia sensors by detecting vibration from blood vessels.

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