Structure and immunological activity of a novel polysaccharide from the spores of Ganoderma lucidum

L, Zhang; Zhang, Y

doi:10.5897/ajb11.2847

Cited by 11 publications

(4 citation statements)

References 21 publications

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“…Substitute compounds with lower levels seem to be more active than higher ones [ 49 ]. SGP showed a dose-dependent stimulation of lymphocyte proliferation in mice induced by concanavalin A and lipopolysaccharide [ 50 ].…”

Section: Reviewmentioning

confidence: 99%

Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review

Thuy,

Tu,

Thu

et al. 2023

Cureus

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Ganoderma lucidum is traditionally used to prevent and treat some diseases such as liver disorders, hypertension, insomnia, diabetes, and cancer. G. lucidum spore extracts are also reported to share similar bioactivities as extracts from its other parts. However, there is no systematic review that elucidates its pharmacological effect. Our aim is to comprehensively summarise current evidence of G. lucidum spore extracts to clarify its benefits to be applied in further studies. We searched five primary databases: PubMed, Virtual Health Library (VHL), Global Health Library (GHL), System for Information on Grey Literature in Europe (SIGLE), and Google Scholar on September 13, 2021. Articles were selected according to inclusion and exclusion criteria. A manual search was applied to find more relevant articles. Ninety studies that reported the pharmacological effects and/or safety of G. lucidum spores were included in this review. The review found that G. lucidum spore extracts showed quite similar effects as other parts of this medicinal plant including anti-tumor, anti-inflammatory, antioxidant effects, and immunomodulation. G. lucidum sporoderm-broken extract demonstrated higher efficiency than unbroken spore extract. G. lucidum extracts also showed their effects on some genes responsible for the body's metabolism, which implied the benefits in metabolic diseases. The safety of G. lucidum should be investigated in depth as high doses of the extract could increase levels of cancer antigen (CA)72-4, despite no harmful effect shown on body organs. Generally, there is a lot of potential in the studies of compounds with pharmacological effects and new treatments. Sporoderm breaking technique could contribute to the production of extracts with more effective prevention and treatment of diseases. High doses of G. lucidum spore extract should be used with caution as there was a concern about the increase in CA.

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Section: Reviewmentioning

confidence: 99%

Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review

Thuy,

Tu,

Thu

et al. 2023

Cureus

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“…O gênero Ganoderma, conhecido há milênios na medicina tradicional chinesa, é altamente valorizado por suas propriedades imunológicas e antioxidantes Zhang, 2011;Zhao et al, 2020). Com mais de 100 espécies descritas, esses macrofungos têm sido amplamente explorados na medicina moderna, com uma variedade de produtos fitoterápicos derivados disponíveis no mercado, incluindo pós, chás, extratos e suplementos alimentares (Wachtel-Galor et al, 2012).…”

Section: Introductionunclassified

Perspectivas do potencial imunomodulador e antineoplásico de polissacarídeos e outras biomoléculas de Ganoderma spp.

Silva,

Chevreuil,

Silva

et al. 2024

OLEL

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Os polissacarídeos derivados de espécies fúngicas pertencentes ao gênero Ganoderma têm sido reconhecidos como agentes importantes tanto na modulação do sistema imunológico quanto na inibição do crescimento tumoral. Este estudo objetivou destacar a capacidade antineoplásica e imunomoduladora in vitro dos polissacarídeos de Ganoderma. Foi demonstrado que esses polissacarídeos são capazes de estimular a atividade de células imunes, fortalecendo assim resposta imunológica contra células tumorais. Adicionalmente, esses compostos naturais mostram-se capazes de prevenir, bloquear ou mesmo reverter o desenvolvimento do câncer, com potencial para mitigar os efeitos colaterais associados aos tratamentos convencionais. É importante ressaltar que esses compostos também exibem atividades antineoplásicas, retardando o crescimento e a disseminação de tumores. O potencial imunomodulador e antineoplásico dos polissacarídeos de Ganoderma pode representar uma fonte promissora de tratamentos adjuvantes e alternativos para o câncer e outras doenças relacionadas ao sistema imunológico. Diante dos desafios e limitações da quimioterapia, os medicamentos fitoterápicos emergem como alternativas promissoras no tratamento do câncer. Nesse contexto, os polissacarídeos extraídos de Ganoderma, um cogumelo medicinal, despertam crescente interesse devido às suas propriedades comprovadas de quimioprevenção e antineoplásicas.

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“…Snails are rich in beneficial ingredients, the polysaccharide derivative isolated from A. fulica can selectively block angiogenesis in an inflammatory model induced by VEGF (vascular endothelial growth factor), and it is speculated the bioactive polysaccharide may have some health promoting activity [14]. A rot fungus is called “ Heimiella retispora” by the Chinese, and it has been used to improve human health and longevity in the past millennium [18]. Many studies have confirmed polysaccharides isolated from H. retispora possess many special characteristics, such as improving insulin sensitivity and having anti-inflammatory, immunomodulatory anti-inflammatory, and anti-tumor properties [18,19,20,21].…”

Section: Introductionmentioning

confidence: 99%

“…A rot fungus is called “ Heimiella retispora” by the Chinese, and it has been used to improve human health and longevity in the past millennium [18]. Many studies have confirmed polysaccharides isolated from H. retispora possess many special characteristics, such as improving insulin sensitivity and having anti-inflammatory, immunomodulatory anti-inflammatory, and anti-tumor properties [18,19,20,21]. H. retispora have flourished in the food and pharmaceutical industries in recent years.…”

Section: Introductionmentioning

confidence: 99%

Functional Analysis of Macromolecular Polysaccharides: Whitening, Moisturizing, Anti-Oxidant, and Cell Proliferation

et al. 2019

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In this research we utilized extracts from two different nature products, Achatina fulica and Heimiella retispora, to enhance skin moisturizing abilities, anti-oxidative properties, and cell proliferations. It was observed that two polysaccharides with anti-oxidative effects by chelating metal ions reduced oxidative stress and further blocked the formation of reactive oxygen species syntheses. To detect whether there was a similar effect within the cellular mechanism, a flow cytometry was applied for sensing the oxidative level and it was found that both materials inhibited the endogenous oxidative stress, which was induced by phorbol-12-myristate-13-acetate (PMA). Both polysaccharides also stimulated the production of collagen to maintain skin tightness and a moisturizing effect. In summary, we developed two macromolecular polysaccharides with potential applications in dermal care.

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Structure and immunological activity of a novel polysaccharide from the spores of Ganoderma lucidum

Cited by 11 publications

References 21 publications

Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review

Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review

Perspectivas do potencial imunomodulador e antineoplásico de polissacarídeos e outras biomoléculas de Ganoderma spp.

Functional Analysis of Macromolecular Polysaccharides: Whitening, Moisturizing, Anti-Oxidant, and Cell Proliferation

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