Structure and magnetism of novel dinuclear cobalt(II) complexes

Mihalčiak, Jakub; Bertová, Petra; Růžičková, Zdeňka; Moncóľ, Ján; Segľa, Peter; Boča, Roman

doi:10.1016/j.inoche.2015.03.038

Cited by 7 publications

(2 citation statements)

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“…4 ). In type I, there are only two bridging carboxylato-O,O′ ligands showing a Co…Co distance in the range 3.917–4.030 Å [ 69 , 70 ]. The two carboxylato-O,O′ bridges may be also combined with one aqua bridge (type II) or two hydroxo bridges (type III) increasing the total number of bridges to three [ [71] , [72] , [73] , [74] ] and four [ 69 ], respectively.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, structural determination, in vitro and in silico biological evaluation of divalent or trivalent cobalt complexes with indomethacin

Perontsis

Geromichalou

Perdih

et al. 2020

Journal of Inorganic Biochemistry

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The interaction of cobalt chloride with the non-steroidal anti-inflammatory drug indomethacin (Hindo) led to the formation of the polymeric complex [Co(indo-O) 2 (H 2 O) 2 (μ-Cl)] n ·n(MeOH·H 2 O) bearing one chlorido bridge between the cobalt atoms. The presence of the nitrogen-donor co-ligands 2,2′-bipyridine (bipy), 2,2′-bipyridylamine (bipyam), 1,10-phenanthroline (phen) or 1 H -imidazole (Himi) resulted in the isolation of complexes [Co 2 (μ-indo-O,O′) 2 (indo-O) 2 (bipy) 2 (μ-H 2 O)]·3.3MeOH, [Co(indo-O,O′) 2 (bipyam)]·0.9MeOH·0.2H 2 O, [Co(indo-O,O′) 2 (phen)] ( 4 ) and [Co(indo-O) 2 (Himi) 2 ] ( 5 ), respectively, where the indomethacin ligands were coordinated in diverse manners. The study of the affinity of the complexes for calf-thymus DNA revealed their intercalation between the DNA-bases. The binding of the complexes to albumins was also examined and the corresponding binding constants and binding subdomain were determined. The free radical scavenging activity of the compounds was evaluated towards 1,1-diphenyl-picrylhydrazyl and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid). Molecular modeling calculations may usually provide a molecular basis for the understanding of both the impairment of DNA by its binding with the studied complexes and the ability of these compounds to transportation through serum albumin proteins. This study can provide information for the elucidation of the mechanism of action of the compounds in a molecular level.

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Section: Resultsmentioning

confidence: 99%

Synthesis, structural determination, in vitro and in silico biological evaluation of divalent or trivalent cobalt complexes with indomethacin

Perontsis

Geromichalou

Perdih

et al. 2020

Journal of Inorganic Biochemistry

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show abstract

“…Coordination polymers (CPs) have attracted interest for more than three decades owing to their structural versatility, which often gives rise to distinctive chemical and physical properties. , As a result, CPs have a range of potential applications, including the storage, − separation, , and sensing of small guest molecules, , as well as catalysis − and magnetism. − A fundamental understanding of the structure–property relationships of CPs is essential for the rational design of dynamic functional materials based on such systems. Typically, these studies benefit substantially from structural transformations that occur in a single-crystal to single-crystal (SC-SC) manner.…”

Section: Introductionmentioning

confidence: 99%