Structure and mechanics of the vitreoretinal interface

Phillips, Joseph D.; Hwang, Eileen S.; Morgan, Denise J.; Creveling, Christopher J.; Coats, Brittany

doi:10.1016/j.jmbbm.2022.105399

Cited by 7 publications

(3 citation statements)

References 94 publications

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“…This prevalence is higher than that in controls with adjusted age. VMIA was considered to be pathogenesis of ARMD, as traction would lead to pigment epithelial detachment and spread of VEGF [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of vitreomacular interface in neovascular age-related macular degeneration treated with intravitreal injection of anti-VEGF

et al. 2022

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Background The purpose of this study is to study the effect of repeated intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs on vitreomacular interface. Methods Neovascular age-related macular degeneration patients who received intravitreal injections of anti-VEGF drugs were included. Eyes with severe vitreous opacity, uveitis, complicated cataract surgery and previous vitrectomy were excluded. Vitreomacular interface, best corrected visual acuity (BCVA) and central retinal thickness (CRT) assessment were performed once a month for at least 3 months. The nature and time of the change event are recorded. Groups were divided according to whether vitreomacular interface change events occurred. To analyse the risk factors of vitreomacular interface changes and their influence on treatment effect. Results A total of 87 eyes were evaluated. Vitreomacular interface change event occurred in 9 eyes. Pre-existing vitreomacular interface abnormality (VMIA) was a risk factor for the VMI change (P = 0.033, OR = 16.518, 95% CI: 1.258 to 216.939). 60% of interface events occurred in the first 3 months of treatment. The final BCVA of eyes with vitreomacular interface unchanged was significantly higher than that at baseline (P = 0.001), and the final CRT was also significantly lower than that at baseline (P < 0.001). The final CRT of eyes vitreomacular interface changed was significantly lower than that at baseline (P = 0.015), however, there was no statistical significance in BCVA (P = 0.468). Conclusion Intravitreal injection of anti-VEGF drugs has a certain probability to cause changes in the vitreomacular interface, and the risk is higher in eyes with pre-existing vitreomacular interface abnormality. The effect of intravitreal injections on the vitreomacular interface was concentrated in the first three injections, and subsequent increases in the number of injections did not significantly increase the risk of vitreomacular interface abnormality. Ophthalmologists should increase attention to the vitreomacular interface in the early stages of anti-VEGF therapy and counsel patients accordingly.

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Section: Discussionmentioning

confidence: 99%

The effect of vitreomacular interface in neovascular age-related macular degeneration treated with intravitreal injection of anti-VEGF

et al. 2022

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“…When there are strong focal vitreoretinal adhesions, it can impede complete PVD. Such adhesions can apply tension on the retina, causing macular holes, and epiretinal membranes (ERMs) in the macula [ 13 ].…”

Section: Reviewmentioning

confidence: 99%

Role of the Vitreous in Retinal Pathology: A Narrative Review

Popescu,

Munteanu,

Patoni

et al. 2023

Cureus

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The vitreous body is an anatomically and biochemically complex structure. Because of its proximity and firm adherence to the retina, researchers have examined the link between these two structures and how their individual pathologies might be connected. Several experimental and clinical studies have already demonstrated the important role of vitreous in the pathogenesis of retinal disorders. This narrative review highlights the role of the vitreous in retinal diseases and the improvements that have been made since the introduction of optical coherence tomography. This leads to a better understanding of vitreoretinal diseases and demonstrates its determinant role in other retinal pathologies, such as diabetic retinopathy or age-related macular degeneration. As we deepen our knowledge of the vitreous's structure, function, and abnormal conditions, we can better link the changes in diseases and identify effective treatments.

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“…With the enlargement of ocular volume and vitreous liqui cation, the adhesion between retinal and vitreous increased, combined with abnormal posterior vitreous detachment, especially in patients with high myopia patients. Adhesions at the vitreoretinal interface apply traction to the retina, leading to a range of tractional retinopathies 5 . The prevalence of VMT in the Chinese population is reported to be about 2.4% in myopia patients 6 .…”

Section: Introductionmentioning

confidence: 99%

Paravascular Vitreous Adhesions in Patients with Myopia Under 30 Years by Swept Source Optical Coherence Tomography

She¹,

Xie²,

Yao³

et al. 2022

Preprint

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Objectives: To present the characteristics of paravascular vitreous adhesions in patients with myopia under 30 years by SS-OCT. Methods: This was a cross-sectional study. One eye of each subject was enrolled in the study, and the paravascular, macular and optic disc regions were scanned by SS-OCT.The PVA was classified to 4 degrees, Grade 1: No visible separation. Grade2: A slit structure visible, Grade 3: Distinguished separation, but remains to the retina. Grade 4: Complete separation. The degree of macular posterior vitreous detachment (PVD), location of vitreoschisis and presence of granular hyper reflection structure were evaluated and compared within high myopic groups using SPSS. Results: A total of 31 highly myopic eyes and 78 non-highly myopic eyes were enrolled from 5 to 29 years. The varying degrees of PVA in the superior and inferior vascular arch was 29.9% (32), 19.6% (21), 27.1%(29) and 23.4%(25) and 28.6%(30), 17.1%(18), 23.8%(25) and 30.5%(32) separately for 1 to 4 degree of PVA. The degrees of PVA were higher in patients with high myopia than in normal people (P< 0.01). A higher degree of PVA was related to macular PVD and the presence of vitreoschisis (P< 0.05). The granular hyper-reflection structure was mainly in patients without high myopia and was positively related to vitreoschisis (P=0.006, r=0.265). Conclusions: Highly myopic subjects had a higher grade of paravascular vitreous adhesion and the presence of vitreoschisis. The degree of PVA was associated with the macular vitreous adhesion. The granular hyper-reflection structure may play a role in vitreous adhesion.

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Structure and mechanics of the vitreoretinal interface

Cited by 7 publications

References 94 publications

The effect of vitreomacular interface in neovascular age-related macular degeneration treated with intravitreal injection of anti-VEGF

The effect of vitreomacular interface in neovascular age-related macular degeneration treated with intravitreal injection of anti-VEGF

Role of the Vitreous in Retinal Pathology: A Narrative Review

Paravascular Vitreous Adhesions in Patients with Myopia Under 30 Years by Swept Source Optical Coherence Tomography

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