Structure and Physiological Actions of Ghrelin

Delporte, Christine

doi:10.1155/2013/518909

Cited by 162 publications

(156 citation statements)

References 374 publications

(470 reference statements)

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“…Ghrelin, a peptide hormone mainly produced by the stomach (1), has emerged as an important gut-brain signal to control growth hormone secretion, food intake, and reward-seeking behaviors (2,3). Ghrelin mediates these actions through the growth hormone secretagogue type 1a (GHS-R1a) 2 receptor, a family A G protein-coupled receptor (GPCR) (4,5).…”

mentioning

confidence: 99%

Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling

M’Kadmi

Leyris

Onfroy

et al. 2015

Journal of Biological Chemistry

107

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Background: GHS-R1a activates multiple signaling pathways mediating feeding and addictive behaviors. Results: Some GHS-R1a ligands activate G q but not G i/o and fail to recruit ␤-arrestin2; others act as selective inverse agonists at G q compared with G 13 . Conclusion: Synthetic ligands can selectively activate or reverse G q -dependent signaling at GHS-R1a. Significance: Ligand-biased signaling can be exploited for the development of selective drugs to treat GHS-R1a-mediated disorders.

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mentioning

confidence: 99%

Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling

M’Kadmi

Leyris

Onfroy

et al. 2015

Journal of Biological Chemistry

107

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“…The Structurally, ghrelin is made from a preproghrelin with 117 amino acids which contains a 23 AA signal peptide and a 66 AA carboxyterminal peptide called C-ghrelin and this segmant of preproghrelin is further processed to a 23AA peptide named obestatin [30]. It has to be noted that nascent ghrelin peptide , derived from the ghrelin gene transcription and translation are subjected t a posttranslational modification process consisting in acylation of hydroxyl group of the serine 3, and two form of ghrelin acylated and nonacylated has been recognized [29][30][31].…”

Section: Aerobic Exercise and Herb Supplementation Increase Liver Andmentioning

confidence: 99%

“…It has to be noted that nascent ghrelin peptide , derived from the ghrelin gene transcription and translation are subjected t a posttranslational modification process consisting in acylation of hydroxyl group of the serine 3, and two form of ghrelin acylated and nonacylated has been recognized [29][30][31]. The enzyme responsible for ghrelin acylation is ghrelin O-acyltransferase (GOAT) belonging to the family of membrane O-acyl transferase [31].…”

Section: Aerobic Exercise and Herb Supplementation Increase Liver Andmentioning

confidence: 99%

Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression

Shirvani¹,

Ghanbari–Niaki²,

Rahmati-Ahmadabad

et al. 2017

Int J Appl Exerc Physiol

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ABSTRACT:The aim of present study was to investigate the effects of aerobic training with and without Pistacia-atlantica (Bane) extraction as a plant rich in fatty acids, on rat tissues nesfatin-1/nucleobindin-2 and ghrelin gene expression and also on plasma lipid and lipoproteins profiles.Twenty healthy and intact Wistar rats were obtain and randomly were assigned into saline-control (SC), saline-training (ST), Bane-control (BC), and Bane-training (BT) groups. Training groups ran on a motor driven treadmill (at intensity 25m/min, 5days/wk.) for 8 weeks. Rats were orally received saline or bene solution (100 mg/kg and 7.5ul/g of body weight). Blood was collected to determine biochemical variables and liver and visceral fat were also obtain for Nesfatin-1/nucleobindin-2 and ghrelin mRNA expressions by using a Real-time PCR technique.A higher and significant nesfatin-1 mRNA expressions in liver and visceral fat and liver estradiol were observed in trained groups. However, the level of ghrelin expression was lower in trained groups when compared to control rats. In general, lower tissues nesfatin-1mRNA expression and lower plasma and higher estradiol HDL-C were observed in bane-treated rats. A negative and positive correlation between liver estradiol and liver ghrelin expression, plasma estradiol, HDL-C and visceral fat nesfatin-1 expression were found respectively. The results of present study indicate that exercise combined with bane-treatment induced considerable changes on liver and visceral fat nesfatin-1 and ghrelin expression which was accompanied with a significant change in plasma HDL-C as a cardiovascular risk factor.

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“…Inverse correlations were reported between ghrelin and BMI or fat mass [10,11]. Studies on eating behaviors suggest that ghrelin is not only dependent on body fat mass, but also influenced by the nutritional status [9]. Therefore, considering the low BMI and eating disorders in AIS, we hypothesized that ghrelin anomaly may be involved in scoliosis and that AIS patients may have abnormal circulating ghrelin levels.…”

Section: Introductionmentioning

confidence: 98%

Fasting total ghrelin levels are increased in patients with adolescent idiopathic scoliosis

Gennero¹,

Conte-Auriol²,

Mus³

et al. 2013

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Background: A control study was designed to investigate circulating Ghrelin levels in adolescent girls with adolescent idiopathic scoliosis (AIS) and controls. Eating behavioral disorders, endocrine disorders, abnormal growth pattern and osteopenia have been well documented in AIS. Ghrelin is an orexigenic hormone produced by the stomach which reflects body weight changes and stimulates growth hormone secretion. Recently, it has been shown to be associated with bone metabolism and eating behavior. However, the circulating levels of ghrelin have never been evaluated in AIS patients. Methods: Forty nine AIS girls and 15 controls were included. Anthropometric parameters and fasting circulating total ghrelin were measured. Curve severity was evaluated in AIS girls. The relationships between ghrelin and age, body weight, height, body mass index (BMI), BMI Z-score and corrected anthropometric parameters were analyzed in AIS girls and controls. Results: There was no significant difference in body weight, height, BMI or BMI Z-score between AIS and controls. Serum ghrelin level was 1.8 fold higher in AIS girls than in controls. Elevation of ghrelin levels remained significant when corrected BMI or corrected BMI Z-score were considered. Unlike in controls, positive correlations were found between ghrelin and age in AIS girls with a gradual increase of circulating ghrelin with age. Conclusions: We have observed significantly higher circulating ghrelin levels in AIS than in controls with a positive correlation with age. This pilot-study suggests that ghrelin signaling might play a role in the initiation or development of AIS. Further studies are needed to validate theses results.

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Structure and Physiological Actions of Ghrelin

Cited by 162 publications

References 374 publications

Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling

Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling

Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression

Fasting total ghrelin levels are increased in patients with adolescent idiopathic scoliosis

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