Structure and plant growth activity relationship in terpenoid lactones

Kalsi, P. S.; Sood, V.B.; Masih, Aruna B.; Gupta, D. N.; Talwar, K. K.

doi:10.1016/s0031-9422(00)84020-0

Cited by 23 publications

(12 citation statements)

References 7 publications

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“…All of these data are in good accordance with previous results obtained for the root-promoting activity of some guaianolides and some other sesquiterpenes (Kalsi et al, 1981(Kalsi et al, , 1983.…”

Section: Resultssupporting

confidence: 92%

Sesquiterpene Lactones with Potential Use as Natural Herbicide Models (I): trans,trans-Germacranolides

Macías

Galindo

Castellano

et al. 1999

J. Agric. Food Chem.

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A structure-activity study to evaluate the effect of the trans, trans-germacranolide sesquiterpene lactones costunolide, parthenolide, and their 1,10-epoxy and 11,13-dihydro derivatives (in a range of 100-0.001 microM) on the growth and germination of several mono and dicotyledon target species is accomplished. Results are compared with those obtained in the same bioassay with an internal standard, the commercial herbicide Logran, to validate the results with a known active formulation and to compare the results with a commercial product to test their potential use as natural herbicide models. These compounds appear to have a more selective effects on the radicle growth of monocotyledons. Certain factors such as the presence of nucleophile-acceptor groups and their accessibility enhance the inhibitory activity. The levels of radicle inhibition obtained with some compounds on wheat are totally comparable to those of Logran and allow to propose them as lead compounds.

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Section: Resultssupporting

confidence: 92%

Sesquiterpene Lactones with Potential Use as Natural Herbicide Models (I): trans,trans-Germacranolides

Macías

Galindo

Castellano

et al. 1999

J. Agric. Food Chem.

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“…Root-promoting action of dehydrocostuslactone (1) was enhanced tremendously with the formation of an epoxy group at C(4) as in compound I [64], and a similar case was reported previously by Kalsi et al [210]. Compound J with an epoxy ring at C(13), as expected [211], was also much more potent than the parent a-methylidene-g-lactone [67]. No additional increase in this biological activity occurred due to a second epoxy ring at C(10), and the epimeric epoxide, K, individually showed root-promoting activity comparable to that of I [64].…”

Section: Otherssupporting

confidence: 84%

“…It has been further established that, only in the case of guaianolides, the presence of a C(4)-epoxy or a C(4)ÀOÀC(10) ether group further enhance the biological activity [210] compared with the parent lactone. A similar effect of the epoxy group was not observed in the case of eudesmanolides [211]. Moreover, the presence of a OH group at C(4) or C(10), and an oxirane at C(10) had no such effect [210].…”

Section: Othersmentioning

confidence: 89%

ChemInform Abstract: Secondary Metabolites of Plants from the Genus Saussurea: Chemistry and Biological Activity

Dong

Cong

et al. 2011

ChemInform

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“…Compound J with an epoxy ring at C(13), as expected [211], was also much more potent than the parent a-methylidene-g-lactone [67]. No additional increase in this biological activity occurred due to a second epoxy ring at C(10), and the epimeric epoxide, K, individually showed root-promoting activity comparable to that of I [64].…”

Section: Otherssupporting

confidence: 53%

Section: Othersmentioning

confidence: 53%

Secondary Metabolites of Plants from the Genus Saussurea: Chemistry and Biological Activity

Wang

Dong

et al. 2010

Chemistry & Biodiversity

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The Asteraceae family comprises ca. 1000 genera, mainly distributed in Asia and Europe. Saussurea DC., as the largest subgenus of this family, comprises ca. 400 species worldwide, of which ca. 300 species occur in China. Most plants in China grow wild in the alpine zone of the Qingzang Plateau and adjacent regions at elevations of 4000 m. Plants of the genus Saussurea (Asteraceae) are used in both traditional Chinese folk medicine and Tibet folklore medicine, since they are efficacious in relieving internal heat or fever, harmonizing menstruation, invigorating blood circulation, stopping bleeding, alleviating pain, increasing energy, and curing rheumatic arthritis. A large number of biologically active compounds have been isolated from this genus. This review shows the chemotaxonomy of these compounds (215 compounds) such as sesquiterpenoids (101 compounds), flavonoids (19 compounds), phytosterols (15 compounds), triterpenoids (25 compounds), lignans (32 compounds), phenolics (23 compounds), and chlorophylls (11 compounds). Biological activities (anti-inflammatory, anticancer, antitumor, hepatoprotective, anti-ulcer, cholagogic, immunosuppressive, spasmolytic, antimicrobial, antiparasitic, antifeedant, CNS depressant, antioxidant, etc.) of these compounds, including structure-activity relationships, are also discussed.

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Structure and plant growth activity relationship in terpenoid lactones

Cited by 23 publications

References 7 publications

Sesquiterpene Lactones with Potential Use as Natural Herbicide Models (I): trans,trans-Germacranolides

Sesquiterpene Lactones with Potential Use as Natural Herbicide Models (I): trans,trans-Germacranolides

ChemInform Abstract: Secondary Metabolites of Plants from the Genus Saussurea: Chemistry and Biological Activity

Secondary Metabolites of Plants from the Genus Saussurea: Chemistry and Biological Activity

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