Structure and Production of Casomorphins

Haq, Ul; Raies, Mohammad

doi:10.1007/978-981-15-6102-3_2

Cited by 2 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous study has found this substance in urine after galactose administration [90], and it might also be a prebiotic (HMO) present in HM [91]. Neocasomorphin, found in our HM samples, is a casein-derived peptide with opioid function [92]. Phosphatidic acids as the one identified in our analysis are a class of phospholipids and main components of the milk fat globules, also associated with proteins in the human milk aqueous phase [93].…”

Section: Discussionsupporting

confidence: 55%

Post Natal Microbial and Metabolite Transmission: The Path from Mother to Infant

Vélez-Ixta,

Juárez-Castelán,

Ramírez-Sánchez

et al. 2024

Nutrients

View full text Add to dashboard Cite

The entero–mammary pathway is a specialized route that selectively translocates bacteria to the newborn’s gut, playing a crucial role in neonatal development. Previous studies report shared bacterial and archaeal taxa between human milk and neonatal intestine. However, the functional implications for neonatal development are not fully understood due to limited evidence. This study aimed to identify and characterize the microbiota and metabolome of human milk, mother, and infant stool samples using high-throughput DNA sequencing and FT-ICR MS methodology at delivery and 4 months post-partum. Twenty-one mothers and twenty-five infants were included in this study. Our results on bacterial composition suggest vertical transmission of bacteria through breastfeeding, with major changes occurring during the first 4 months of life. Metabolite chemical characterization sheds light on the growing complexity of the metabolites. Further data integration and network analysis disclosed the interactions between different bacteria and metabolites in the biological system as well as possible unknown pathways. Our findings suggest a shared bacteriome in breastfed mother–neonate pairs, influenced by maternal lifestyle and delivery conditions, serving as probiotic agents in infants for their healthy development. Also, the presence of food biomarkers in infants suggests their origin from breast milk, implying selective vertical transmission of these features.

show abstract

Section: Discussionsupporting

confidence: 55%

Post Natal Microbial and Metabolite Transmission: The Path from Mother to Infant

Vélez-Ixta,

Juárez-Castelán,

Ramírez-Sánchez

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…The difference between A1 and A2 β-casein lies in the specific amino acid at a particular position (the 67th position) in the protein sequence. A1 β-casein contains the amino acid histidine at this position in its protein sequence, whereas A2 β-casein has the amino acid proline [4][5][6]. The pasteurization (85 • C/30 s) and UHT (140 • C/15 s) of milk inhibit the formation of BCM7 during intestinal digestion, which could be due to the protein denaturation altering the protein digestion [3,[7][8][9] or due to the formation of radicals during the Maillard reaction that could attack the protein backbone, subsequently modifying some of the peptides that are formed [10].…”

Section: Introductionmentioning

confidence: 99%