Structure and prolonged transport in a biodegradable poly(R-3-hydroxybutyrate)-drug system

Abstract

In order to create new biodegradable systems for the targeted transport of drugs, poly(3 hydroxy butyrate) films containing the antibiotic rifampicin in an amount of 5-15 wt % as a model drug are prepared. Film surfaces are studied via scanning electron microscopy, and various structural elements (globules and fibrils) are found. Polymer samples isolated from melt or solution feature different degrees of porosity. It is shown that the kinetic profiles of rifampicin release are of an abnormal character. An analysis of the profiles shows that the release of rifampicin is controlled by the superposition of two processes: its desorption via the diffusion mechanism (the nonlinear segment) and hydrolytic degradation of poly(3 hydroxybutyrate) (the extended linear segment), which becomes well defined after completion of the diffusion stage. The diffusionkinetic model of the process is developed.

Electrospinning of Fiber Matrices from Polyhydroxybutyrate for the Controlled Release Drug Delivery Systems

“…In many previous reports, the structure formation of fibrillar materials based on PHB-containing dipyridamole (DPD) [59], chitosan [60], titanium dioxide and silicon nanoparticles [61], iron (III)-chlorporphyrin complexes [62], etc. was considered.…”

Thermo-Oxidative Destruction and Biodegradation of Nanomaterials from Composites of Poly(3-hydroxybutyrate) and Chitosan

“…The most promising system from this view is a blend of PHB and CHT [ 19 ]. As was shown in the example of film matrices [ 20 ], the combination of PHB and CHT allowed to create of a new generation of amphiphilic fully biodegradable composite systems with an increased sorption capacity, a controlled rate of biodegradation, and the ability to implement various kinetic profiles of prolonged release of a low-molecular-weight substance in a wide time range (from weeks to months).…”

Ultrathin Poly(3-hydroxybutyrate) Fibers: Structure and Dynamic Characteristics

“…In previous works [11; 12; 20], for the examples of the natural polyester poly(3-hydroxybutyrate) (PHB) and a number of its compositions with other polymers, the physico-+chemical, dynamic, and transport characteristics of macroscopic biodegradable matrixes and microparticles of PHB that are prospective for prolonged and controlled drug delivery were studied [13].…”