Structure and properties of acidic polysaccharides isolated from Massa Medicata Fermentata: Neuroprotective and antioxidant activity

Liu, Shuang; Li, Meng; Liu, Wenwen; Zhang, Zhe; Wang, Xiao; Dong, Hongjing

doi:10.1016/j.ijbiomac.2023.129128

Cited by 5 publications

(1 citation statement)

References 64 publications

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“…The characteristic functional groups of DOPs were analyzed via FTIR and the results are presented in Figure 7 . As shown, these four samples all exhibited obvious absorption peaks at 3400~3450 cm −1 and 2850~2950 cm −1 , which corresponded to the stretching vibrations of O–H bonds and C–H bonds respectively, suggesting the characteristic absorption peaks of polysaccharides [ 29 , 30 ]. In particular, the peaks observed at around 1735 cm −1 in DOP-1 and DOP-2 could be attributed to the vibrational motion of the esterified carboxyl groups’ carbonyl double bonds (C=O) in an asymmetric stretching manner [ 31 ], indicating the acetyl modification located at O–2 of Man p and Glc p [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of Ethanol Concentrations on Primary Structural and Bioactive Characteristics of Dendrobium officinale Polysaccharides

Yu,

Long,

Chi

et al. 2024

Nutrients

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Ethanol fractional precipitation can initially separate polysaccharides according to the structure, which exhibits strong correlation with the biological activities. This study aimed to investigate the impact of varying ethanol concentrations on the structural characteristics, and the antitumor and antioxidant activities of polysaccharides derived from Dendrobium officinale through ethanol fractional precipitation, as well as their internal relationships. The polysaccharides acquired by absolute alcohol additions at a final liquor-ethanol volume ratio of 1:1, 1:2, and 1:4 were named DOP-1, DOP-2, and DOP-4, and the supernatant was named DOP-S. The results of the structural analysis revealed that the increase in ethanol concentrations resulted in a reduction in the molecular weights and the acetylation degree of the polysaccharides, as well as a decrease in mannose content and an increase in glucose content. In vitro experiments demonstrated that DOP-S exhibited optimal antitumor and antioxidant activities. Animal experiments further confirmed that DOP-S suppressed the growth of solid tumors significantly, enhanced lymphocytes, mediated immune ability, and improved the activity of antioxidant enzymes. These findings would establish a theoretical foundation and provide technical support for further advances and applications of polysaccharides derived from D. officinale in the fields of food and medicine.

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