Structure and Properties of Cyclic Polymethylene Ureas, III. Synthesis and Biological Activity of Some Mannich Bases of Tetrahydro‐2‐(1H)‐Pyrimidinone

Abstract

Some N-mono-2a-e and N,N'-bis(aminomethy1) derivatives 3a-b of tetrahydro-2-( 1H)-pynmidinone l a and tetrahydro-2( 1H)-pyrimidinethione l e are obtained by the Munnich reaction of l a or l e with formaldehyde and secondary amines. The compounds show a marked antiviral activity. Struktur und Eigenschaften cydicher Polymethylen-Harnstoffe, 3. Mitt.: Synthese und biologische Aktivitat von einigen Tetrahydro-2(1H)-Pyrimidinon-Mannich-Basen Es wurden N-mono-2a-e und N,N'-bis-aminomethyl-Derivate 3a-b von Tetrahydro-2-( 1H)-pyrimidinon la und Tetrahydro-2(1H)-pyrimidinthion l e durch Munnich Reaktion von l a oder l e mit 0365-6233/82/0M)&00509 $ 02.50/0 0 Verlag Chemie GmbH. Weinheim 1982

Cycluridine: A novel antiviral effective against flaviviruses

“…Planned synthesis based on our previous work on N, N 0 -disubstituted ureas and thioureas with antiviral effects [23][24][25] resulted in a series of cyclic urea and thiourea derivatives and related compounds: tetrahydro-2(1H)pyrimidinones and tetrahydro-2(1H)-pyrimidinethions 26 (I, II):…”

Antiphytoviral activity of 1‐morpholinomethyl‐tetrahydro‐2(1H)‐pyrimidinone (DD13)

“…1-Morpholinomethyl-tetrahydro-2(1H)-pyrimidinone (D13) synthesized according to Sidzhakova et al (1982) was studied:…”