Structure and Properties of Hydrophobic Aggregation Hydrogel with Chemical Sensitive Switch

Duan, Jiufang; Jiang, Jianxin

doi:10.1155/2017/9123248

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…Increasing the XG and XGMA-GelMA concentration increased the hydrogel storage modulus (figure 3(a)-III)), as a result of an increase in physical cross-linking density and viscosity of the solution [53]. In addition, an increased G ′ value was observed in XGMA-GelMA when compared to XG hydrogels, where XGMA was the major contributor to the viscosity for the XGMA-GelMA gel at 37 • C. This could be due to the slight hydrophobic nature of the methacrylate groups, or the formation of stronger hydrogen bonds influenced by the hydrogen bond donor and/or the neighbouring groups (such as methacrylate groups), affecting the material viscosity [54][55][56].…”

Section: Rheological Characterizationmentioning

confidence: 98%

Printability and bio-functionality of a shear thinning methacrylated xanthan–gelatin composite bioink

et al. 2021

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3D bioprinting is a recent technique that can create complex cell seeded scaffolds and therefore holds great promise to revolutionize the biomedical sector by combining materials and structures that more closely mimic the 3D cell environment in tissues. The most commonly used biomaterials for printing are hydrogels, however, many of the hydrogels used still present issues of printability, stability, or poor cell-material interactions. We propose that bioinks with intrinsic self-assembling and shear thinning properties, such as xanthan gum, can be methacrylated (XGMA) and combined with a bio-functional material such as gelatin methacryloyl (GelMa) to create a stable, cell-interactive bioink with improved properties for 3D bioprinting. These biomaterials have reduced viscosity under high shear and recover their viscosity rapidly after the shear is removed, retaining their shape, which translates to easier extrusion whilst maintaining accurate fidelity after printing. This was confirmed in printing studies, with measured normalized strand widths of 1.2 obtained for high gel concentrations (5+5 % XGMA-GelMA). Furthermore, the introduction of a secondary photo-cross-linking method allowed tuning of the mechanical properties of the hydrogel with stiffness between 15 and 30 kPa, as well as improving the stability of the hydrogel with retention of 75 % of its mass after 90 d. The hydrogel was shown to be biocompatible and bio-active with 97 % cell viability, and cell spreading after 7 d of culture for low gel concentrations (3+3 % XGMA-GelMA). Shear stresses were relatively low while printing (1 kPa) as a result of the shear thinning property of the material, which supported cell viability during extrusion. Finally, printed hydrogels retained high cell viability for lower gel concentrations, and showed improved cell viability for more concentrated hydrogels when compared to cells cultured in bulk hydrogels, presumably due to improved nutrient/oxygen diffusion and cell migration. In conclusion, stability and formulation of a XGMA-GelMA shear thinning composite hydrogel has been optimized to create a bio-functional bioink, with improved printability, and in vitro culture stability via secondary photo-induced cross-linking, making this composite a promising bioink for 3D bioprinting.

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Section: Rheological Characterizationmentioning

confidence: 98%

Printability and bio-functionality of a shear thinning methacrylated xanthan–gelatin composite bioink

et al. 2021

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“…Cross-linking is an effective method for reducing the viscosity and swelling power of galactomannan by increasing the molecular weight and the formation of cross-linkages (Cunha et al 2005;Bahamdan et al 2007). Therefore, studying the role of hydrophobic force in improving the mechanical strength and self-repairing property of the melon gel material is an important question (Duan et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a high strength self-repairing galactomannan hydrogel

Duan

Gao

Huang

et al. 2019

BioRes

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Autonomous self-repairing properties can prolong the service life of materials. In this paper, galactomannan hydrogel with high mechanical strength was prepared by graft copolymerization of galactomannan with acrylamide and octadecyl methacrylate in aqueous solution. The microstructure, water absorption property, self-healing behavior, and mechanical properties of the hydrogels were investigated using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM), etc. The galactomannan hydrogel had the highest tensile strength of 49 KPa and strain of 3000%. The water absorption reached 2340%, and the removal rate of methylene blue was more than 80%. Galactomannan hydrogels demonstrated significant self-healing properties. The cut hydrogel was quite effective in self-repairing in a few minutes, and the self-repairing strength increased with increasing contact time of hydrogel cut surfaces. The healing efficiency of fracture strain could reach 92.7% of the original sample in 10 h. The maximum water absorption of hydrogel reached 2340%. The maximum removal rate of methylene blue by hydrogel reached 80.5%, and the maximum adsorption capacity was 19.3 mg/g. The novelty of the work lies in octadecyl methacrylate being used for galactomannan cross-linking with the ability to self-repair after fracture. The galactomannan self-healing hydrogel has potential in water treatment and sealing technology.

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“…Currently, numerous scientific researches on hydrogels as Drug Delivery Systems have been reported in [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is a particularly interesting hydrogel because it is biodegradable.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application

Díaz-Guerrero

Castillo-Miranda

Castro-Guerrero

et al. 2019

International Journal of Polymer Science

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Hydrogels are commonly used as Drug Delivery Systems (DDS) as patches due to its ability to store drug molecules within their structures. The release can be activated under certain stimuli, such as temperature and pH. In this paper, the mathematical modelling of acetaminophen release in hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is reported. The HPC/PAAm gel was synthesized in proportions of 25/75 wt% and was characterized by FTIR, DSC, optical microscopy, SEM, and TGA, with and without acetaminophen. The release tests were performed for hypothermic, normal, and febrile human body conditions, at 35, 37, and 39°C, respectively, on two release media: water and phosphate buffer solution. In order to describe the release of acetaminophen in HPC/PAAm gel, a genetic programming algorithm was used to accomplish Multigene Symbolic Regression (MSR). Characterization results showed that the drug was crystallized on the surface of the HPC/PAAm gel. Release test results showed that several simultaneous processes occurred in the acetaminophen diffusion phenomenon. A unique mathematical model was obtained by MSR. This model was able to describe the release of acetaminophen in HPC/PAAm gel with high values of R 2 and adjusted R 2 and to simulate the drug release at times beyond the end of the experiment. High values of R 2 and low values of Coefficient of Variation (CV), Root-Mean-Square Error (RMSE), and Mean Absolute Error (MAE) were obtained from the comparison between the simulated and the experimental data. This allows to conclude that the mathematical model is reliable to represent and simulate the acetaminophen release in HPC/PAAm gel at 35, 37, and 39°C.

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Structure and Properties of Hydrophobic Aggregation Hydrogel with Chemical Sensitive Switch

Cited by 6 publications

References 16 publications

Printability and bio-functionality of a shear thinning methacrylated xanthan–gelatin composite bioink

Printability and bio-functionality of a shear thinning methacrylated xanthan–gelatin composite bioink

Preparation and characterization of a high strength self-repairing galactomannan hydrogel

Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application

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