This article discusses issues related to the development of technological solutions designed to obtain protective paint and varnish coatings with high operational resistance for building metal structures. The developed technological map and scheme for creating nanostructured paint and varnish coatings on the surfaces of building metal structures are presented. These proposals complement the comprehensive approach to the development of protective paint and varnish coatings, consisting of methodological, technological and formulation solutions, and presented in other studies by the authors, which allows for its effective use in paint and varnish industry enterprises. The research results, based on the application of the developed solutions in laboratory and operational conditions, confirm the high efficiency of the developed integrated approach. Assessment of the quality of coatings in laboratory conditions showed that coating samples after 100 hours of thermal exposure retain high properties that meet the operating conditions of building metal structures. As part of production testing, it was established that the service life of nanostructured coatings increases by 1.5–2.6 times compared to traditional coatings. In this regard, the costs of repair and restoration of coatings are reduced, and their service life between repairs is increased. The introduction of the developed solutions into production will solve the problem of low operational durability of protective paint and varnish coatings of steel building metal structures operated under various influences.