Structure and Properties of Poly(<i>ε</i>‐caprolactone) Networks with Modulated Water Uptake

Ivirico, Jorge L. Escobar; Salmerón-Sánchez, Manuel; Serra, Roser Sabater i; Dueñas, José María Meseguer; Ribelles, J.L. Gómez; Pradas, Manuel Monleón

doi:10.1002/macp.200600399

Cited by 28 publications

(35 citation statements)

References 14 publications

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“…In Ref. [16] it was shown that PCL blocks in PCL-PHEA copolymer networks keep a certain capacity to crystallize as shown by DSC studies. Nevertheless, the behavior of PLLA-PHEA system is not the same.…”

Section: Resultsmentioning

confidence: 99%

“…Co-polymerization is a usual strategy to decrease the crystallinity since the regularity required for crystalline order is disrupted by the presence of different monomeric units randomly distributed along the polymer chain. If the co-monomer is hydrophilic, as in the case with hydroxyethyl acrylate, the water absorption increases, facilitating water access to the polymer chains [16,20,26,27].…”

Section: Resultsmentioning

confidence: 99%

“…Nonetheless two glass transitions are detected by calorimetry, they do approach to each other in the network with respect to that of the homopolymers, indicating a certain miscibility [18]. Nevertheless, phase separation in the PCL-PHEA system permits the formation of PCL crystals and thus, the hydrophilic component is probably segregated in higher extent [16]. This observation shows the importance of the spatial distribution of hydrophilic groups in the network that either allows, or not, water migration to the sample.…”

Section: Resultsmentioning

confidence: 99%

“…PCL-PHEA and PLLA-PHEA copolymer networks containing a 30% by weight of PHEA blocks were synthesized according to previous studies [16,18]. The network hydrogels synthesis consists of three main steps:…”

Section: Polymer Synthesis and Characterizationmentioning

confidence: 99%

See 3 more Smart Citations

Biodegradable polyester networks including hydrophilic groups favor BMSCs differentiation and can be eroded by macrophage action

Fernández

Oberti

Vikingsson

et al. 2016

Polymer Degradation and Stability

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a b s t r a c tThe aim of this study is to show that introducing a small fraction of hydrophilic groups into a hydrophobic polyester favor the macrophage activity by accelerating the degradation action in aqueous media. It is also seen that differentiation of MSCs cultured in monolayer towards bone in specific differentiation media is favored in these materials with respect to the corresponding pristine polyesters. Polymer networks based in polycarpolactone or poly(L-lactide) and containing a small fraction of poly(-hydroxyethyl acrylate) have been synthesized. Degradation kinetics in vitro was monitored by mass loss and swelling capacity of the polymer network in good solvents, the later as representative of chain cleavage. Hydrolytic and enzymatic degradation is accelerated by the inclusion of poly(hydroxyethyl acrylate) blocks in the network. Macrophages were cultured on the surface of the network films, showing its capacity to erode the material surface but also to accelerate bulk degradation. Bone marrow mesenchymal stem cells were cultured in monolayer on the membranes in osteogenic media, showing an increase of specific markers expression in comparison to pristine polyesters.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Polymer Synthesis and Characterizationmentioning

confidence: 99%

See 2 more Smart Citations

Biodegradable polyester networks including hydrophilic groups favor BMSCs differentiation and can be eroded by macrophage action

Fernández

Oberti

Vikingsson

et al. 2016

Polymer Degradation and Stability

Self Cite

View full text Add to dashboard Cite

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“…A few years ago, our group reported a new strategy for crosslinking and obtaining a hydrophilic polycaprolactone [16]. A PCL macromer was synthesized through the reaction of PCL diol with methacrylic anhydride in order to obtain methacrylate end capped PCL.…”

Section: Introductionmentioning

confidence: 99%

Hydrolytic and enzymatic degradation of a poly(ε-caprolactone) network

Castilla-Cortázar¹,

Más-Estellés²,

Dueñas³

et al. 2012

Polymer Degradation and Stability

149

116

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Long-term hydrolytic and enzymatic degradation profiles of poly(ε-caprolactone) (PCL) networks were obtained. The hydrolytic degradation studies were performed in water and phosphate buffer solution (PBS) for 65 weeks. In this case, the degradation rate of PCL networks was faster than previous results in the literature on linear PCL, reaching a weight loss of around 20% in 60 weeks after immersing the samples either in water or PBS conditions. The enzymatic degradation rate in Pseudomonas Lipase for 14 weeks was also studied, with the conclusion being that the degradation profile of PCL networks is lower than for linear PCL, also reaching a 20% weight loss. The weight lost, degree of swelling, and calorimetric and mechanical properties as a function of degradation time were obtained. Furthermore, the morphological changes in the samples were studied carefully through electron microscopy and crystal size through X-ray diffraction. The changes in some properties over the degradation period such as crystallinity, crystal size and Young's modulus were smaller in the case of enzymatic studies, highlighting differences in the degradation mechanism in the two studies, hydrolytic and enzymatic.

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From Chain Growth to Step Growth Polymerization of Photoreactive Poly‐ε‐Caprolactone: The Network Topology of Bioresorbable Networks as Tool in Tissue Engineering

Thijssen

Parmentier

Augustyniak

et al. 2022

Adv Funct Materials

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Control of the network topology by selection of an appropriate cross‐linking chemistry is introduced as a new strategy to improve the elasticity and toughness of bioresorbable networks. The development of novel photocross‐linkable and bioresorbable oligomers is essential for the application of light‐based 3D‐printing techniques in the context of tissue engineering. Although light‐based 3D‐printing techniques are characterized by an increased resolution and manufacturing speed as compared to extrusion‐based 3D‐printing, their application remains limited. Via chemical modification, poly‐ε‐caprolactone (PCL) is functionalized with photoreactive end groups such as acrylates, alkenes, and alkynes. Based on these precursors, networks with different topologies are designed via chain growth polymerization, step growth polymerization, or a combination thereof. The influence of the network topology and the concomitant cross‐linking chemistry on the thermal, mechanical, and biological properties are elucidated together with their applicability in digital light processing (DLP). Photocross‐linkable PCL with an elongation at break of 736.3 ± 47% and an ultimate strength of 21.3 ± 0.8 MPa is realized, which is approximately tenfold higher compared to the current state‐of‐the‐art. Finally, extremely elastic DLP‐printed dog bones are developed which can fully retrieve their initial length upon stress relieve at an elongation of 1000%.

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Structure and Properties of Poly(ε‐caprolactone) Networks with Modulated Water Uptake

Cited by 28 publications

References 14 publications

Biodegradable polyester networks including hydrophilic groups favor BMSCs differentiation and can be eroded by macrophage action

Biodegradable polyester networks including hydrophilic groups favor BMSCs differentiation and can be eroded by macrophage action

Hydrolytic and enzymatic degradation of a poly(ε-caprolactone) network

From Chain Growth to Step Growth Polymerization of Photoreactive Poly‐ε‐Caprolactone: The Network Topology of Bioresorbable Networks as Tool in Tissue Engineering

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