Structure and properties of spider and silkworm silk for tissue scaffolds

Guinea, Gustavo V.; Calafat, Manuel Elices; Pérez‐Rigueiro, José; Plaza, Gustavo R.

doi:10.1533/9780857097064.2.239

Cited by 4 publications

(2 citation statements)

References 102 publications

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“…γ-Irradiation of degummed B. mori silk fibers showed a decrease in tensile strength starting from ∼50 kGy, 110 while films made from regenerated A. yamamai, A. perny, or B. mori silk fibroin showed a decrease beginning at 25 kGy. 109 This decrease in tensile properties is attributed to weakening of hydrogen bonds, 127 creation of surface irregularities such as pits and grooves via etching or ablation of surface layers, 94,105 and differences in the interface between the modified and the unmodified layer creating stress points. The differing reports of changes in mechanical properties following surface treatment of different silk formats are likely due to the differences in the depth of modification relative to the overall bulk thickness (e.g., modifying the surface of a single fiber vs a woven structure).…”

Section: Effect Of Dry Surface Treatments On Silk Materialsmentioning

confidence: 99%

Dry Surface Treatments of Silk Biomaterials and Their Utility in Biomedical Applications

Lau

Akhavan

Lord

et al. 2020

ACS Biomater. Sci. Eng.

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Silk-based materials are widely used in biomaterial and tissue engineering applications due to their cytocompatibility and tunable mechanical and biodegradation properties. Aqueous-based processing techniques have enabled the fabrication of silk into a broad range of material formats, making it a highly versatile material platform across multiple industries. Utilizing the full potential of silk in biomedical applications frequently requires modification of silk's surface properties. Dry surface modification techniques, including irradiation and plasma treatment, offer an alternative to the conventional wet chemistry strategies to modify the physical and chemical properties of silk materials without compromising their bulk properties. While dry surface modification techniques are more prevalent in textiles and sterilization applications, the range of modifications available and resultant changes to silk materials all point to the utility of dry surface modification for the development of new, functional silk biomaterials. Dry surface treatment affects the surface chemistry, secondary structure, molecular weight, topography, surface energy, and mechanical properties of silk materials. This Review describes and critically evaluates the effect of physical dry surface modification techniques, including irradiation and plasma processes, on silk materials and discusses their utility in biomedical applications, including recent examples of modulation of cell/protein interactions on silk biomaterials, in vivo performance of implanted biomaterials, and applications in material biofunctionalization and lithographic surface patterning approaches.

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Section: Effect Of Dry Surface Treatments On Silk Materialsmentioning

confidence: 99%

Dry Surface Treatments of Silk Biomaterials and Their Utility in Biomedical Applications

Lau

Akhavan

Lord

et al. 2020

ACS Biomater. Sci. Eng.

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“…Diferente do bicho-da-seda, essas aranhas não tiveram sua produção domesticada devido à baixa quantidade de seda que esses animais são capazes de produzir. Além disso, são animais de natureza solitária e predatória, o que dificulta o cultivo em larga escala(GUINEA et al, 2015; MATSUMOTO et al, 2007).São Paulo e Paraná, os quais, até hoje, dominam a produção nacional, sob o controle de interesses japoneses (DATTA; NANAVATY, 2007). Segundo dados do Global Silk Production Statistics de 2018, o Brasil ocupa hoje o 5º lugar dentre os maiores produtores de seda do mundo.2.6.2 Composição da sedaA fibra da seda produzida pelo bicho-da-seda Bombyx mori é composta majoritariamente por duas proteínas, a fibroína em dois filamentos na camada interior, revestida por uma camada exterior de sericina, além de outras impurezas naturais como gorduras, ceras, sais inorgânicos e pigmentos (MONDAL; TRIVEDY;KUMAR, 2007; UDE et al, 2014).…”

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Desenvolvimento de partículas a partir da blenda de sericina e alginato para incorporação e liberação modificada de anti-inflamatórios cetoprofeno e naproxeno

Dantas de Freitas

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Bioactive Silk‐Based Nerve Guidance Conduits for Augmenting Peripheral Nerve Repair

Magaz

Faroni

Gough

et al. 2018

Adv Healthcare Materials

105

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Repair of peripheral nerve injuries depends upon complex biology stemming from the manifold and challenging injury-healing processes of the peripheral nervous system. While surgical treatment options are available, they tend to be characterized by poor clinical outcomes for the injured patients. This is particularly apparent in the clinical management of a nerve gap whereby nerve autograft remains the best clinical option despite numerous limitations; in addition, effective repair becomes progressively more difficult with larger gaps. Nerve conduit strategies based on tissue engineering approaches and the use of silk as scaffolding material have attracted much attention in recent years to overcome these limitations and meet the clinical demand of large gap nerve repair. This review examines the scientific advances made with silk-based conduits for peripheral nerve repair. The focus is on enhancing bioactivity of the conduits in terms of physical guidance cues, inner wall and lumen modification, and imbuing novel conductive functionalities.

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Structure and properties of spider and silkworm silk for tissue scaffolds

Cited by 4 publications

References 102 publications

Dry Surface Treatments of Silk Biomaterials and Their Utility in Biomedical Applications

Dry Surface Treatments of Silk Biomaterials and Their Utility in Biomedical Applications

Desenvolvimento de partículas a partir da blenda de sericina e alginato para incorporação e liberação modificada de anti-inflamatórios cetoprofeno e naproxeno

Bioactive Silk‐Based Nerve Guidance Conduits for Augmenting Peripheral Nerve Repair

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