Structure and Properties of Thermomechanically Processed Chitosan-Based Biomimetic Composite Materials: Effect of Chitosan Molecular Weight

Zhang, Linhua; Gao, Chengcheng; Wang, Zhenjiong; Xie, Fengwei; Chen, Ying; Meng, Linghan; Tang, Xiaozhi

doi:10.1021/acssuschemeng.2c05843

Cited by 10 publications

(5 citation statements)

References 65 publications

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“…FT-IR studies were conducted to identify the functional groups on the modified CS particles (Figure ). In the spectrum of the CS particles, peaks at 1153 and 897 cm –1 were assigned to the saccharide structure. The broad peak at 3373 cm –1 was attributed to the −OH and −NH groups of CS.…”

Section: Resultsmentioning

confidence: 99%

pH-Responsive Liquid Marbles Stabilized with Chitosan-Stearic Acid-Conjugated Particles

Kunanopparatn,

Hayashi,

Atsuta

et al. 2024

ACS Sustainable Chem. Eng.

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Liquid marbles (LMs) are liquid droplets covered by hydrophobic solid particles adsorbed at liquid−gas interfaces. In this study, we designed pH-responsive LMs by using chitosan (CS) particles conjugated with stearic acid (SA) as a stabilizer, both of which are natural materials. Micrometer-sized CS-SA-conjugated particles were synthesized via a sustainable route based on solvent-free and one-pot thermal amidation between CS and SA. The resulting particles were extensively characterized on multiple scales by determining their sizes, shapes, morphologies, bulk/ surface chemical compositions, hydrophilic−hydrophobic balances, and pHresponsive behaviors. The heterogeneous reactions only occurred near the particle surface, and the CS-SA-conjugated particles showed hydrophobic surfaces and pH-responsive cores. Millimeter-and centimeter-sized LMs with liquid contents ranging between 15 μL and 1.0 mL were readily prepared by rolling water droplets over a dried CS-SA particle powder bed. Stereomicroscopy studies confirmed that the CS-SA particles were adsorbed at the surfaces of the water droplets as mono-and bilayers, resulting in stable LMs. These LMs showed long-term stability (>2 h) under a water vapor atmosphere but were disrupted immediately (<2 min) when exposed to HCl vapor, with wetting of the particles by the inner aqueous solution. Here, acid vaporinduced disruption was realized with the "response cascade" concept: the initial pH stimulus led to disruption via intermediate wetting responses. We also demonstrated the use of LMs as colorimetric sensors for amines generated during food spoilage.

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Section: Resultsmentioning

confidence: 99%

pH-Responsive Liquid Marbles Stabilized with Chitosan-Stearic Acid-Conjugated Particles

Kunanopparatn,

Hayashi,

Atsuta

et al. 2024

ACS Sustainable Chem. Eng.

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“…Moreover, higher molecular weight chitosan chains have more amino groups, which can form more hydrogen bonds with other chitosan molecules, further contributing to the material's mechanical strength. 43 Therefore, increasing either the chitosan concentration or molecular weight can improve the mechanical properties of chitosan-based materials, which is crucial for developing materials with better performance and broader applications. The compressive strength of the composite made of modified high molecular weight chitosan was found between 0.12 MPa and 1.3 MPa.…”

Section: Resultsmentioning

confidence: 99%

Mechanical and thermal properties of polyvinyl acetate foams reinforced with biopolymers

Ergun,

Ozen,

Yildirim

et al. 2023

Cellular Polymers

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The study developed and designed polyvinyl acetate (PVAc) foams using advanced freeze-drying technology, which exhibited good heat-insulating ability, flame retardancy, and mechanical properties. Different combinations of bleach kraft pulp, water-soluble chitosan, and zinc borate were used to reinforce the foams. The foams exhibited desirable compression and flexural properties, with compression strength and compression modulus ranging from 0.01 MPa to 0.08 MPa and 0.05 MPa to 0.29 MPa, respectively, while flexural strength and flexural modulus ranged from 0.12 MPa to 5.37 MPa and 9.86 MPa to 260,85 MPa, respectively. The use of zinc borate as a reinforcement resulted in improved thermal properties and reduced mass loss at 600°C by 20.69%. Thermal conductivity tests indicated that the foams had low thermal conductivity values ranging from 0.037 W/mK to 0.074 W/mK. The foams with zinc borate (60 g/L) and high molecular weight water-soluble chitosan (70 g/L) reinforcement exhibited high limiting oxygen index (LOI) of 28.72%. Overall, the results suggest that the PVAc foams could serve as a promising sustainable alternative in thermal insulation and construction fields.

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“…The parameters of pectin are unfortunately not specified. The use of high-molecular-weight chitosan in our case is due to the possibility of using it to vary the mechanical properties of materials in a wide range of values [64].…”

Section: Discussionmentioning

confidence: 99%

Rational Design of Pectin–Chitosan Polyelectrolyte Nanoparticles for Enhanced Temozolomide Delivery in Brain Tumor Therapy

Silant’ev,

Belousov,

Trukhin

et al. 2024

Biomedicines

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Conventional chemotherapeutic approaches currently used for brain tumor treatment have low efficiency in targeted drug delivery and often have non-target toxicity. Development of stable and effective drug delivery vehicles for the most incurable diseases is one of the urgent biomedical challenges. We have developed polymer nanoparticles (NPs) with improved temozolomide (TMZ) delivery for promising brain tumor therapy, performing a rational design of polyelectrolyte complexes of oppositely charged polysaccharides of cationic chitosan and anionic pectin. The NPs’ diameter (30 to 330 nm) and zeta-potential (−29 to 73 mV) varied according to the initial mass ratios of the biopolymers. The evaluation of nanomechanical parameters of native NPs demonstrated changes in Young’s modulus from 58 to 234 kPa and adhesion from −0.3 to −3.57 pN. Possible mechanisms of NPs’ formation preliminary based on ionic interactions between ionogenic functional groups were proposed by IR spectroscopy and dynamic rheology. The study of the parameters and kinetics of TMZ sorption made it possible to identify compounds that most effectively immobilize and release the active substance in model liquids that simulate the internal environment of the body. A polyelectrolyte carrier based on an equal ratio of pectin–chitosan (0.1% by weight) was selected as the most effective for the delivery of TMZ among a series of obtained NPs, which indicates a promising approach to the treatment of brain tumors.

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Structure and Properties of Thermomechanically Processed Chitosan-Based Biomimetic Composite Materials: Effect of Chitosan Molecular Weight

Cited by 10 publications

References 65 publications

pH-Responsive Liquid Marbles Stabilized with Chitosan-Stearic Acid-Conjugated Particles

pH-Responsive Liquid Marbles Stabilized with Chitosan-Stearic Acid-Conjugated Particles

Mechanical and thermal properties of polyvinyl acetate foams reinforced with biopolymers

Rational Design of Pectin–Chitosan Polyelectrolyte Nanoparticles for Enhanced Temozolomide Delivery in Brain Tumor Therapy

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