Structure and radioprotective properties of a non-toxic polysaccharide from Heliantnus tuberosus L.

Spectral characteristics and monosaccharide composition of an interferon-inducing antiviral polysaccharide from Heliantnus tuberosus L.

“…As expected, supernatants of control cultures demon 15 In all dilutions, the polysaccharide induced high levels of IFN production: the observed IFN titers were nearly as high as those induced by such a potent agent as Newcastle disease virus and significantly exceeded IFN levels produced in response to similar concentra tions of gossypol and staphylococcal enterotoxin A (an IFN γ inducer). The fact that the polysaccharide was a stronger IFN inducer than staphylococcal entero toxin A and gossypol suggests that it probably acts as a mixed type inducer of IFN α, β, and γ.…”

“…For the infecting dose of 10 LD 50 , the protective effect was 63-53% for the polysaccharide in comparison to 15% for acyclovir, while for the infecting dose of 100 LD 50 , it was 57-63% in contrast to no effect of acyclovir. It should be pointed out that most known natural IFN inducers (e.g., gossypol, staphylococcal entero toxin A, Newcastle disease virus) and antiviral com pounds are considered inappropriate for clinical applications because of their high toxicity, which is not the case for the polysaccharide that we describe [15]. Our data demonstrating the high antiviral and IFN inducing activity of this polysaccharide suggest that this compound is a promising candidate for applica tion for medical purposes.…”

Antimetastatic and Tumor Growth Inhibition Activity of Polysaccharide from Helianthus Tuberosus L.

“…Most probably antimetastatic activity of HTLP is observed due to immunomodulatory activity. It was shown in previous work [12], that HTLP modulates activity of IL-6 and stimulates secretion of TNF.Tumor necrosis factor affects binding of TNF-α to TNFR-1 that leads to change ofhyperpermeability of the tumor vessels, and erythrocytes and other blood cells extravasate [14] and inducing immune-mediated necrosis of cancers [15,16].At the same time IL-6 promotes epithelialmesenchymal transition, which leads to the growth of metastasis processes in head and neck cancers [15,17], while HTLP decreases level of IL-6 when it is above normal .…”

Polysaccharide Nanoparticles Bearing HDAC Inhibitor as Nontoxic Nanocarrier for Drug Delivery

“…Biocompatibility and biodegradability of the NPs are indispensable prerequisites for materials used as nanocarriers in drug delivery applications. [ 1–4 ]…”